One-Pot Synthesis of Highly Substituted Allenylidene Derivatives via Palladium- or Nickel-Catalyzed Tandem Michael Addition-Cyclization Reaction

A simple and tandem synthetic approach, which offers an efficient, direct route to highly substituted indenes, has been developed by palladium‐ or nickel‐catalyzed cyclization of propargylic compounds and nitrogen nucleophiles. The reaction takes place under mild conditions, and a possible mechansim...

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Bibliographic Details
Published in:Advanced synthesis & catalysis 2009-01, Vol.351 (1-2), p.141-146
Main Authors: Shi, Yun, Huang, Jing, Yang, Yan-Fang, Wu, Lu-Yong, Niu, Yan-Ning, Huo, Peng-Fei, Liu, Xue-Yuan, Liang, Yong-Min
Format: Article
Language:English
Subjects:
allenes
cyclization
nickel
palladium
propargylic compounds
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Summary:A simple and tandem synthetic approach, which offers an efficient, direct route to highly substituted indenes, has been developed by palladium‐ or nickel‐catalyzed cyclization of propargylic compounds and nitrogen nucleophiles. The reaction takes place under mild conditions, and a possible mechansim is proposed.
ISSN:1615-4150
1615-4169
DOI:10.1002/adsc.200800582