Self-assembly of mesoporous silicas hollow microspheres via food grade emulsifiers for delivery systems

Randomly ordered mesoporous silicas hollow microspheres of 20–50μm in diameter with distinguished characteristic of interconnected porosity (7–14nm) of their thin outer walls are developed. Food grade emulsifier polyglycerol esters of fatty acids (PGEFA) are used as a soft-template and n-decane as a...

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Bibliographic Details
Published in:Microporous and mesoporous materials 2010-03, Vol.128 (1-3), p.187-193
Main Authors: Kapoor, Mahendra P., Vinu, Ajayan, Fujii, Wataru, Kimura, Tatsuo, Yang, Qihua, Kasama, Yuuki, Yanagi, Masaaki, Juneja, Lekh R.
Format: Article
Language:English
Subjects:
Chemistry
Colloidal state and disperse state
Delivery systems
Emulsifiers
Exact sciences and technology
Food grade
General and physical chemistry
Hollow microspheres
Micelles. Thin films
Porous materials
Self-assembly
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Summary:Randomly ordered mesoporous silicas hollow microspheres of 20–50μm in diameter with distinguished characteristic of interconnected porosity (7–14nm) of their thin outer walls are developed. Food grade emulsifier polyglycerol esters of fatty acids (PGEFA) are used as a soft-template and n-decane as a swelling agent, which was necessary for the formation of silica doped micelles to improve the mesoporous channel orientation without leading the phase transition. The interconnected pore channels that extend from the outside of the microspheres shell to its inside are used to fill the mesoporous silicas microspheres for enhanced encapsulation of VB3 precursor and cumulative in vitro release of vitamin B3 with considerable rate pharmacokinetics using simple pH trigger mechanism for the delivery systems.
ISSN:1387-1811
1873-3093
DOI:10.1016/j.micromeso.2009.08.019