Stimulation of membrane ruffling and MAP kinase activation by district effectors of RAS

The RAS guanine nucleotide binding proteins activate multiple signaling events that regulate cell growth and differentiation. Test results indicate that membrane ruffling and activation of MAP kinase represent distinct RAS effector pathways and that input from both pathways is required for the mitog...

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Bibliographic Details
Published in:Science (American Association for the Advancement of Science) 1996-02, Vol.271 (5250), p.810-810
Main Authors: Joneson, Tom, White, Michael A, Wigler, Michael H, Bar-Sagi, Dafna
Format: Article
Language:English
Subjects:
Cellular biology
Deoxyribonucleic acid
DNA
Molecular biology
Online Access:Get full text
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Summary:The RAS guanine nucleotide binding proteins activate multiple signaling events that regulate cell growth and differentiation. Test results indicate that membrane ruffling and activation of MAP kinase represent distinct RAS effector pathways and that input from both pathways is required for the mitogenic activity of RAS.
ISSN:0036-8075
1095-9203