Structural and functional basis for GABA A receptor heterogeneity

When gamma-aminobutyric acid (GABA), the major inhibitory neurotransmitter in vertebrate brain, binds to its receptor it activates a chloride channel. A study which isolates cDNAs encoding two additional GABAA receptor alpha-subunits and confirms the heterogeneous nature of the receptor/chloride cha...

Full description

Saved in:
Bibliographic Details
Published in:Nature (London) 1988-09, Vol.335 (6185), p.76-79
Main Authors: Levitan, Edwin S, Schofield, Peter R, Burt, David R, Rhee, Lucy M, Wisden, William, Köhler, Martin, Fujita, Norihisa, Rodriguez, Henry F, Stephenson, Anne, Darlison, Mark G, Barnard, Eric A, Seeburg, Peter H
Format: Article
Language:English
Subjects:
Brain
Cellular biology
Genetics
Heterogeneity
Medical research
Nervous system
Vertebrates
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:When gamma-aminobutyric acid (GABA), the major inhibitory neurotransmitter in vertebrate brain, binds to its receptor it activates a chloride channel. A study which isolates cDNAs encoding two additional GABAA receptor alpha-subunits and confirms the heterogeneous nature of the receptor/chloride channel complex is discussed.
ISSN:0028-0836
1476-4687