Structural parts involved in activation and inactivation of the sodium channel

Structure–function relationships of the sodium channel expressed in Xenopus oocytes have been investigated by the combined use of site–directed mutagenesis and patch-clamp recording. This study provides evidence that the positive charges in segment S4 are involved in the voltage–sensing mechanism fo...

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Bibliographic Details
Published in:Nature (London) 1989-06, Vol.339 (6226), p.597-603
Main Authors: Stühmer, Walter, Conti, Franco, Suzuki, Harukazu, Wang, Xiaodong, Noda, Masaharu, Yahagi, Naoki, Kubo, Hideo, Numa, Shosaku
Format: Article
Language:English
Subjects:
Action Potentials
Animals
Biological and medical sciences
Cell physiology
Chemistry
DNA
Fundamental and applied biological sciences. Psychology
Humanities and Social Sciences
Inactivation
Membrane and intracellular transports
Molecular and cellular biology
multidisciplinary
Mutation
oocytes
Ovum
Plasmids
Science
Science (multidisciplinary)
Sodium
Sodium Channels
Structure-Activity Relationship
Transfection
Xenopus
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Summary:Structure–function relationships of the sodium channel expressed in Xenopus oocytes have been investigated by the combined use of site–directed mutagenesis and patch-clamp recording. This study provides evidence that the positive charges in segment S4 are involved in the voltage–sensing mechanism for activation of the channel and that the region between repeats III and IV is important for its inactivation.
ISSN:0028-0836
1476-4687
DOI:10.1038/339597a0