Microbial transformation of diosgenin and its precursor furostanol glycosides

Microorganisms have been screened for biotransformational activity against diosgenin or its precursor furostanol glycosides obtained from fenugreek seed (Trigonella foenum-graecum). Using diosgenin as the substrate, Cunninghamella elegans and Aspergillus nidulans produced some androstenes when α,α&#...

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Bibliographic Details
Published in:World journal of microbiology & biotechnology 2009-03, Vol.25 (3), p.481-487
Main Authors: Adham, Nehad Zaki, Zaki, Rania Anwar, Naim, Nadia
Format: Article
Language:English
Subjects:
Applied Microbiology
Aspergillus nidulans
Bacteria
Biochemistry
Bioconversions. Hemisynthesis
Biological and medical sciences
Biomedical and Life Sciences
Biotechnology
Chemicals
Chromatography
Cunninghamella elegans
Environmental Engineering/Biotechnology
Fundamental and applied biological sciences. Psychology
Fungi
Life Sciences
Methods. Procedures. Technologies
Microbiology
Microorganisms
Organisms
Original Paper
Pharmaceutical industry
Quantitative analysis
Rhizopus
Seeds
Solvents
Steroids
Studies
Trigonella foenum-graecum
Yeast
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Summary:Microorganisms have been screened for biotransformational activity against diosgenin or its precursor furostanol glycosides obtained from fenugreek seed (Trigonella foenum-graecum). Using diosgenin as the substrate, Cunninghamella elegans and Aspergillus nidulans produced some androstenes when α,α'-dipyridyl was supplemented to the transformation medium. Also, using the glycosides as a substrate, Rhizopus sp. produced diosgenin in >90% yield from the glycoside. The parameters were optimized to increase the yield of the androstenes.
ISSN:0959-3993
1573-0972
DOI:10.1007/s11274-008-9913-1