Synthesis, Physico-Chemical Properties and Immunoadjuvant Activity of Water-Soluble Phosphazene Polyacids

Mixed-substituted polyphosphazenes containing carboxylic acid and alkyl ether side groups were synthesized and characterized. Physicochemical properties of phosphazene polyacids in aqueous solutions were investigated as a function of copolymer structure and composition. The immunoadjuvant activity o...

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Bibliographic Details
Published in:Journal of bioactive and compatible polymers 1998-10, Vol.13 (4), p.243-256
Main Authors: Andrianov, Alexander K., Sargent, Jonathan R., Sule, Sameer S., Le Golvan, Mark P., Woods, Angela L., Jenkins, Sharon A., Payne, Lendon G.
Format: Article
Language:English
Subjects:
Biological and medical sciences
General pharmacology
Influenza virus
Medical sciences
Miscellaneous
Pharmacology. Drug treatments
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Summary:Mixed-substituted polyphosphazenes containing carboxylic acid and alkyl ether side groups were synthesized and characterized. Physicochemical properties of phosphazene polyacids in aqueous solutions were investigated as a function of copolymer structure and composition. The immunoadjuvant activity of polyphosphazenes was evaluated by studying the effect of copolymers on the immunogenicity of the influenza virus in mice. Synthesized polyphosphazenes demonstrated the ability to enhance the immune response as compared to the levels elicited by the vaccine alone.
ISSN:0883-9115
1530-8030
DOI:10.1177/088391159801300401