Tissue Response to Biodegradable Injectable Microcapsules

Biodegradable microcapsules have been shown to be capable of delivering a sustained release of various medicinal agents. We have observed an initial minimal, sharply localized, acute inflammatory response to intramuscularly injected microcapsules produced from various polymers. Evaluation of later t...

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Bibliographic Details
Published in:Journal of biomaterials applications 1987, Vol.2 (1), p.118-131
Main Authors: Visscher, G.E., Robison, R.L., Argentieri, G.J.
Format: Article
Language:English
Subjects:
Animals
Biocompatible Materials
Biodegradation, Environmental
Biological and medical sciences
Capsules
Drug Implants
Foreign-Body Reaction - pathology
General pharmacology
Lypressin - administration & dosage
Male
Medical sciences
Microscopy, Electron, Scanning
Muscles - pathology
Pharmaceutical technology. Pharmaceutical industry
Pharmacology. Drug treatments
Rats
Rats, Inbred Strains
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Summary:Biodegradable microcapsules have been shown to be capable of delivering a sustained release of various medicinal agents. We have observed an initial minimal, sharply localized, acute inflammatory response to intramuscularly injected microcapsules produced from various polymers. Evaluation of later time points has shown a diminishing macrophage, foreign body giant cell, and connective tissue response along with actual microcapsule degradation. No fibrous capsule formation was seen. Complete resolution of the tissue reaction can be expected, with the time frame depending upon the polymer utilized. Published experimental results report similar minor tissue responses to a variety of injected biodegradable microcapsules.
ISSN:0885-3282
1530-8022
DOI:10.1177/088532828700200103