Tissue Response to Biodegradable Injectable Microcapsules

Biodegradable microcapsules have been shown to be capable of delivering a sustained release of various medicinal agents. We have observed an initial minimal, sharply localized, acute inflammatory response to intramuscularly injected microcapsules produced from various polymers. Evaluation of later t...

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Published in:Journal of biomaterials applications 1987, Vol.2 (1), p.118-131
Main Authors: Visscher, G.E., Robison, R.L., Argentieri, G.J.
Format: Article
Language:English
Subjects:
Animals
Biocompatible Materials
Biodegradation, Environmental
Biological and medical sciences
Capsules
Drug Implants
Foreign-Body Reaction - pathology
General pharmacology
Lypressin - administration & dosage
Male
Medical sciences
Microscopy, Electron, Scanning
Muscles - pathology
Pharmaceutical technology. Pharmaceutical industry
Pharmacology. Drug treatments
Rats
Rats, Inbred Strains
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cited_by cdi_FETCH-LOGICAL-c344t-faa1718fb115b9dbc1657b25f3dfdbd38c0f5dc6ed9c28fbe1a831735dae94473
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container_end_page 131
container_issue 1
container_start_page 118
container_title Journal of biomaterials applications
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creator Visscher, G.E.
Robison, R.L.
Argentieri, G.J.
description Biodegradable microcapsules have been shown to be capable of delivering a sustained release of various medicinal agents. We have observed an initial minimal, sharply localized, acute inflammatory response to intramuscularly injected microcapsules produced from various polymers. Evaluation of later time points has shown a diminishing macrophage, foreign body giant cell, and connective tissue response along with actual microcapsule degradation. No fibrous capsule formation was seen. Complete resolution of the tissue reaction can be expected, with the time frame depending upon the polymer utilized. Published experimental results report similar minor tissue responses to a variety of injected biodegradable microcapsules.
doi_str_mv 10.1177/088532828700200103
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We have observed an initial minimal, sharply localized, acute inflammatory response to intramuscularly injected microcapsules produced from various polymers. Evaluation of later time points has shown a diminishing macrophage, foreign body giant cell, and connective tissue response along with actual microcapsule degradation. No fibrous capsule formation was seen. Complete resolution of the tissue reaction can be expected, with the time frame depending upon the polymer utilized. 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source SAGE Complete Deep Backfile Purchase 2012
subjects Animals
Biocompatible Materials
Biodegradation, Environmental
Biological and medical sciences
Capsules
Drug Implants
Foreign-Body Reaction - pathology
General pharmacology
Lypressin - administration & dosage
Male
Medical sciences
Microscopy, Electron, Scanning
Muscles - pathology
Pharmaceutical technology. Pharmaceutical industry
Pharmacology. Drug treatments
Rats
Rats, Inbred Strains
title Tissue Response to Biodegradable Injectable Microcapsules
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