Arterial Smooth Muscle Cell Proliferation on a Novel Biomimicking, Biodegradable Vascular Graft Scaffold

A study was conducted to create a biomimicking graft scaffold with collagen fibers for a reinforcement material and a biodegradable matrix material (composite structure). Collagen fibers were spun and a biodegradable PLA matrix was spun around this fiber for smooth muscle cell (SMC) seeding and to h...

Full description

Saved in:
Bibliographic Details
Published in:Journal of biomaterials applications 2001-07, Vol.16 (1), p.22-33
Main Authors: Stitzel, Joel D., Pawlowski, Kristin J., Wnek, Gary E., Simpson, David G., Bowlin, Gary L.
Format: Article
Language:English
Subjects:
Arteries - cytology
Biocompatible Materials
Biodegradation
Biodegradation, Environmental
Biological and medical sciences
Biomimetic materials
Blood Vessel Prosthesis
Blood vessels
Cell Division
Cells
Cells, Cultured
Collagen
Cytology
Implants (surgical)
Medical sciences
Microscopy, Electron, Scanning
Muscle, Smooth, Vascular - cytology
Organic polymers
Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases
Technology. Biomaterials. Equipments
Tissue
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:A study was conducted to create a biomimicking graft scaffold with collagen fibers for a reinforcement material and a biodegradable matrix material (composite structure). Collagen fibers were spun and a biodegradable PLA matrix was spun around this fiber for smooth muscle cell (SMC) seeding and to hold the fibers in place during tissue regeneration. The construct was seeded with human aortic SMCs and the resulting graft was analyzed.
ISSN:0885-3282
1530-8022
DOI:10.1106/U2UU-M9QH-Y0BB-5GYL