Protective effects of fullerenol C60(OH)24 against doxorubicin-induced cardiotoxicity and hepatotoxicity in rats with colorectal cancer

The effects of fullerenol C60(OH)24 (Frl) at doses of 25, 50, and 100mg/kg/week (for a time-span of 3 weeks) on heart and liver tissue after doxorubicin (Dox)-induced toxicity in rats with colorectal cancer were investigated. In the present study, we used an in vivo Wistar male rat model to explore...

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Bibliographic Details
Published in:Biomaterials 2009-02, Vol.30 (6), p.1184-1196
Main Authors: Injac, Rade, Perse, Martina, Cerne, Manica, Potocnik, Nejka, Radic, Natasa, Govedarica, Biljana, Djordjevic, Aleksandar, Cerar, Anton, Strukelj, Borut
Format: Article
Language:English
Subjects:
Abdominal Cavity - pathology
Animals
Body Weight - drug effects
Cardiotoxins - toxicity
Colorectal Neoplasms - blood
Colorectal Neoplasms - enzymology
Colorectal Neoplasms - pathology
Doxorubicin - toxicity
Electrocardiography
Enzymes - blood
Fullerenes - pharmacokinetics
Fullerenes - pharmacology
Glutathione Disulfide - metabolism
Heart - drug effects
Hemodynamics - drug effects
Liver - drug effects
Liver - pathology
Male
Malondialdehyde - metabolism
Myocardium - pathology
Oxidation-Reduction - drug effects
Oxidative Stress - drug effects
Protective Agents - pharmacology
Rats
Rats, Wistar
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Summary:The effects of fullerenol C60(OH)24 (Frl) at doses of 25, 50, and 100mg/kg/week (for a time-span of 3 weeks) on heart and liver tissue after doxorubicin (Dox)-induced toxicity in rats with colorectal cancer were investigated. In the present study, we used an in vivo Wistar male rat model to explore whether Frl could protect against Dox-induced (1.5mg/kg/week for 3 weeks) chronic cardio- and hepato- toxicity and compared the effect with a well-known antioxidant, vitamin C (100mg/kg/week for 3 weeks). According to macroscopic, microscopic, hematological, biochemical, physiological, pharmacological, and pharmacokinetic results, we confirmed that, at all examined doses, Frl exhibits a protective influence on the heart and liver tissue against chronic toxicity induced by Dox.
ISSN:0142-9612
1878-5905
DOI:10.1016/j.biomaterials.2008.10.060