Neonatal Hepatitis Induced by alpha1-Antitrypsin: A Transgenic Mouse Model

A study established transgenic mouse lineages that carry the normal (M) or mutant (Z) alleles of the human alpha1-antitrypsin (alpha 1-Pi) gene. The phenotype of the mice in the strain expressing high levels of the Z allele is remarkably similar to human neonatal hepatitis, thus suggesting that this...

Full description

Saved in:
Bibliographic Details
Published in:Science (American Association for the Advancement of Science) 1988-12, Vol.242 (4884), p.1409-1409
Main Authors: Dycaico, Mark J, Grant, Seth G N, Felts, Katherine, Nichols, W Stephen, Geller, Stephen A
Format: Article
Language:English
Subjects:
Biochemistry
Hepatitis
Medical research
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:A study established transgenic mouse lineages that carry the normal (M) or mutant (Z) alleles of the human alpha1-antitrypsin (alpha 1-Pi) gene. The phenotype of the mice in the strain expressing high levels of the Z allele is remarkably similar to human neonatal hepatitis, thus suggesting that this strain may prove to be a useful animal model for the study of the disease. References.
ISSN:0036-8075
1095-9203