Interaction of poloxamer F-98 with free standing phospholipid films

The interaction of poloxamer F-98 with dimiristoylphosphatidyicholine (DMPC) is investigated experimentally at one (monolayer) and two interacting air/water interfaces (foam film). Monolayer tensiometry reveals the degree of co-polymer penetration in DMPC monolayers and the alterations in monolayer...

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Bibliographic Details
Published in:Journal of Optoelectronics and Advanced Materials 2009-09, Vol.11 (9), p.1241-1243
Main Authors: As Georgiev, G, Jordanova, A G, Ivanov, G R, Lalchev, Z I
Format: Article
Language:English
Online Access:Get full text
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Summary:The interaction of poloxamer F-98 with dimiristoylphosphatidyicholine (DMPC) is investigated experimentally at one (monolayer) and two interacting air/water interfaces (foam film). Monolayer tensiometry reveals the degree of co-polymer penetration in DMPC monolayers and the alterations in monolayer compression/decompression behaviour. The changes in the film morphology are registered by Brewster angle microscopy (BAM). Foam film experiments show that the steric disjoining pressure arising in presence of Poloxamer F-98 results in increase of film equivalent water thickness and stability. It is found that the interaction between the co-polymer and DMPC molecules, both in monolayers and foam films, strongly alters the interfacial properties of the mixed systems, and bears promise for the development of new drug carrier formulations.
ISSN:1454-4164