An Antiinflammatory Galactolipid from Rose Hip (Rosa c anina) that Inhibits Chemotaxis of Human Peripheral Blood Neutrophils in Vitro

The galactolipid (2S)-1,2-di-O-[(9Z,12Z,15Z)-octadeca-9,12,15-trienoyl]-3-O-β-d-galactopyranosyl glycerol (1) isolated from dried and milled fruits of Rosa canina by bioassay-guided fractionation is an antiinflammatory agent with inhibitory effects on chemotaxis of human peripheral blood neutrophils...

Full description

Saved in:
Bibliographic Details
Published in:Journal of natural products (Washington, D.C.) D.C.), 2003-07, Vol.66 (7), p.994-995
Main Authors: Larsen, Erik, Kharazmi, Arsalan, Christensen, Lars P, Christensen, S. Brøgger
Format: Article
Language:English
Subjects:
Adult
anti-inflammatory activity
Anti-Inflammatory Agents, Non-Steroidal
Anti-Inflammatory Agents, Non-Steroidal - chemistry
Anti-Inflammatory Agents, Non-Steroidal - isolation & purification
Anti-Inflammatory Agents, Non-Steroidal - pharmacology
Biological and medical sciences
chemical structure
chemistry
chemotaxis
Chemotaxis - drug effects
Denmark
drug effects
fatty acids
Fruit
Fruit - chemistry
fruits (plant anatomy)
galactolipid
Galactolipids
Galactolipids - chemistry
Galactolipids - isolation & purification
Galactolipids - pharmacology
General pharmacology
glycolipids
Humans
in vivo studies
isolation
isolation & purification
Medical sciences
Molecular Structure
neutrophils
Neutrophils - drug effects
Pharmacognosy. Homeopathy. Health food
pharmacology
Pharmacology. Drug treatments
Rosa
Rosa - chemistry
Rosa canina
Rosaceae
spectral analysis
Stereoisomerism
sugars
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:The galactolipid (2S)-1,2-di-O-[(9Z,12Z,15Z)-octadeca-9,12,15-trienoyl]-3-O-β-d-galactopyranosyl glycerol (1) isolated from dried and milled fruits of Rosa canina by bioassay-guided fractionation is an antiinflammatory agent with inhibitory effects on chemotaxis of human peripheral blood neutrophils in vitro. The inhibition of cell migration is not related to toxicity. The presence of 1 in rose hips may explain the clinically observed antiinflammatory properties of rose hip herbal remedies.
ISSN:0163-3864
1520-6025
DOI:10.1021/np0300636