Prospective 12-month course of bipolar disorder in out-patients with and without comorbid anxiety disorders

The impact of anxiety disorders has not been well delineated in prospective studies of bipolar disorder. To examine the association between anxiety & course of bipolar disorder, as defined by mood episodes, quality of life & role functioning. A thousand out-patients with bipolar disorder wer...

Full description

Saved in:
Bibliographic Details
Published in:British journal of psychiatry 2006-07, Vol.189 (JUL), p.20-25
Main Authors: OTTO, M. W, SIMON, N. M, WEISS, R. D, MIYAHARA, S, THASE, M. E, SACHS, G. S, POLLACK, M. H, WISNIEWSKI, S. R, MIKLOWITZ, D. J, KOGAN, J. N, REILLY-HARRINGTON, N. A, FRANK, E, NIERENBERG, A. A, MARANGELL, L. B, SAGDUYU, K
Format: Article
Language:English
Subjects:
Adult and adolescent clinical studies
Anxiety
Biological and medical sciences
Bipolar affective disorder
Bipolar disorders
Comorbidity
Medical sciences
Mood disorders
Psychology. Psychoanalysis. Psychiatry
Psychopathology. Psychiatry
Quality of life
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:The impact of anxiety disorders has not been well delineated in prospective studies of bipolar disorder. To examine the association between anxiety & course of bipolar disorder, as defined by mood episodes, quality of life & role functioning. A thousand out-patients with bipolar disorder were followed prospectively for 1 year. A current comorbid anxiety disorder (present in 31.9% of participants) was associated with fewer days well, a lower likelihood of timely recovery from depression, risk of earlier relapse, lower quality of life & diminished role function over I year of prospective study. The negative impact was greater with multiple anxiety disorders. Anxiety disorders, including those present during relative euthymia, predicted a poorer bipolar course. The detrimental effects of anxiety were not simply a feature of mood state. Treatment studies targeting anxiety disorders will help to clarify the nature of the impact of anxiety on bipolar course. 2 Tables, 2 Figures, 1 Appendix, 28 References. Adapted from the source document.
ISSN:0007-1250
1472-1465
DOI:10.1192/bjp.bp.104.00773