Cognitive traits link to human chromosomal regions

: Human cognition in normal and disease states is both environmentally and genetically mediated. Except for measures of language-specific abilities, however, few cognitive measures have been associated with specific genes or chromosomal regions. We performed genome-wide linkage analysis of five neur...

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Bibliographic Details
Published in:Behavior genetics 2006-01, Vol.36 (1), p.65-76
Main Authors: Buyske, Steven, Bates, Marsha E, Gharani, Neda, Matise, Tara C, Tischfield, Jay A, Manowitz, Paul
Format: Article
Language:English
Subjects:
Adult
Aged
Alcoholism
Alcoholism - genetics
Alzheimer's disease
Attention
Brain-derived neurotrophic factor
Chromosome Mapping
Chromosomes, Human
Chromosomes, Human, Pair 14
Cognition
Cognition & reasoning
Cognition - physiology
Cognitive ability
Collaboration
Dopamine
Family
Female
Genes
Genetic factors
Genetics
Genomes
Humans
Intelligence
Intelligence Tests
Language disorders
Linkage
Male
Memory
Middle Aged
Neuropsychology
Pedigree
Twins
Visual-Motor performance
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Summary:: Human cognition in normal and disease states is both environmentally and genetically mediated. Except for measures of language-specific abilities, however, few cognitive measures have been associated with specific genes or chromosomal regions. We performed genome-wide linkage analysis of five neuropsychological tests in the Collaborative Study on Genetics of Alcoholism sample. The sample included 1579 individuals (53% female, 76% White Non-Hispanic) in 217 families. There were 390 markers with mean inter-marker distance of 9.6 cM. Performance on the Digit Symbol Substitution Test, a component of the Wechsler Adult Intelligence Scale-R, showed significant linkage to 14q11.2 and suggestive linkage to 14q 24.2. This test of sustained visual attention also involves visual-motor coordination and executive functions. Performance on the WAIS-R Digit Span Test of immediate memory and mental flexibility showed suggestive linkage to 11q 25. Although the validity of these results beyond populations with a susceptibility for alcohol dependence is unclear, these results are among the first linkage results for non-language components of cognition.
ISSN:0001-8244
1573-3297
DOI:10.1007/s10519-005-9008-9