Intrasubject Medication Adherence Patterns

The purpose of this prospective descriptive study was to explore the patterns of intrasubject (between medication) adherence of two similarly timed, twice-daily medications using the Medication Event Management System[R] electronic monitoring cap. Medication adherence was measured for 6 months using...

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Bibliographic Details
Published in:Clinical nursing research 2007-05, Vol.16 (2), p.153-163
Main Authors: Russell, Cynthia L, Conn, Vicki S, Ashbaugh, Catherine, Madsen, Richard, Hayes, Karen, Ross, Gilbert
Format: Article
Language:English
Subjects:
Adherence
Compliance
Electronic monitoring
Immunosuppressive therapy
Prescriptions
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Summary:The purpose of this prospective descriptive study was to explore the patterns of intrasubject (between medication) adherence of two similarly timed, twice-daily medications using the Medication Event Management System[R] electronic monitoring cap. Medication adherence was measured for 6 months using electronic monitoring in 25 adult renal-transplant recipients. Data were available from 7,119 electronic medication events. Results indicated that two twice-daily medications scheduled to be taken simultaneously were taken within 5 min of each other 77% of the time & within 10 min, 92% of the time. When only the first scheduled dose of the day was examined, the results are 79% & 95%, respectively. These findings are important to researchers & clinicians who must evaluate medication adherence in transplant recipients while balancing cost & subject burden. This study provides empirical support for monitoring a single immunosuppressive medication electronically to estimate medication adherence with double or triple immunosuppressive drug therapy. [Copyright 2007 Sage Publications, Inc.]
ISSN:1054-7738
DOI:10.1177/1054773806298429