Elevated prolactin serum levels and history of alcohol withdrawal seizures

Abstract Background Prolactin has been discussed to be useful for differential diagnosis in epilepsia. Aim of the present study was to investigate the association between prolactin serum levels and previous alcohol withdrawal seizures. Methods We assessed 118 male patients admitted for detoxificatio...

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Bibliographic Details
Published in:Journal of psychiatric research 2007-10, Vol.41 (8), p.702-706
Main Authors: Hillemacher, Thomas, Bayerlein, Kristina, Frieling, Helge, Wilhelm, Julia, Ziegenbein, Marc, Kornhuber, Johannes, Bleich, Stefan
Format: Article
Language:English
Subjects:
Addictive behaviors
Adult
Adult and adolescent clinical studies
Alcohol withdrawal
Alcohol Withdrawal Seizures - blood
Alcohol Withdrawal Seizures - diagnosis
Alcohol withdrawal syndrome
Alcoholism
Alcoholism - blood
Alcoholism - rehabilitation
Alcoholism and acute alcohol poisoning
Biological and medical sciences
Biomarkers - blood
Diagnosis, Differential
Female
Glutamate
Headache. Facial pains. Syncopes. Epilepsia. Intracranial hypertension. Brain oedema. Cerebral palsy
Humans
Logistic Models
Male
Medical sciences
Middle Aged
Nervous system (semeiology, syndromes)
Neurology
NMDA receptors
Predictive Value of Tests
Prolactin
Prolactin - blood
Prospective Studies
Psychiatry
Psychology. Psychoanalysis. Psychiatry
Psychopathology. Psychiatry
Risk Factors
Seizures
Toxicology
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Summary:Abstract Background Prolactin has been discussed to be useful for differential diagnosis in epilepsia. Aim of the present study was to investigate the association between prolactin serum levels and previous alcohol withdrawal seizures. Methods We assessed 118 male patients admitted for detoxification treatment. Previous withdrawal seizures were recorded and prolactin serum levels were measured using an enzymatic immunoassay. Results Patients with a history of alcohol withdrawal seizures had significantly higher prolactin levels (17.8 ng/ml, SD = 12.1) than patients without previous seizures (13.0 ng/ml, SD = 8.1, p < 0.05). Logistic regression revealed significant predictive qualities for prolactin serum levels ( B = 0.05, Wald = 5.30, p = 0.021, OR = 1.06, 95%CI = 1.01–1.11). Conclusions The present findings show an association between elevated prolactin serum levels and a history of withdrawal seizures. Hence, the results suggest that prolactin elevation at admission may be a clinical marker for an increased risk of withdrawal seizures.
ISSN:0022-3956
1879-1379
DOI:10.1016/j.jpsychires.2006.01.009