Brief report: Harm avoidance in subjects with obsessive-compulsive disorder and their families

Introduction This study investigates the role of harm avoidance (HA) as a possible risk factor in the familiality of obsessive-compulsive disorder (OCD). HA is considered to be a genetically influenced personality trait with an increasingly understood neuroanatomical basis. Method 75 subjects with O...

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Bibliographic Details
Published in:Journal of affective disorders 2008-04, Vol.107 (1-3), p.265-269
Main Authors: Ettelt, Susan, Grabe, Hans Joergen, Ruhrmann, Stephan, Buhtz, Friederike, Hochrein, Andrea, Kraft, Susanne, Pukrop, Ralf, Klosterkotter, Joachim, Falkai, Peter, Maier, Wolfgang, John, Ulrich, Freyberger, Harald J, Wagner, Michael
Format: Article
Language:English
Subjects:
Avoidance
Families
Harm
Obsessive-Compulsive neuroses
Personality
Risk factors
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Summary:Introduction This study investigates the role of harm avoidance (HA) as a possible risk factor in the familiality of obsessive-compulsive disorder (OCD). HA is considered to be a genetically influenced personality trait with an increasingly understood neuroanatomical basis. Method 75 subjects with OCD from hospital sites and a community sample and their 152 first degree relatives and 75 age and sex matched controls with their 143 first degree relatives were evaluated with structured clinical interviews (DSM-IV). HA was assessed with Cloninger's Tridimensional Personality Questionnaire (TPQ). Results Subjects with OCD had higher scores of HA than controls (p
ISSN:0165-0327
DOI:10.1016/j.jad.2007.08.017