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Efficacy of RTS,S/AS02 malaria vaccine against Plasmodium falciparum infection in semi-immune adult men in the Gambia: a randomised trial
Malaria caused by Plasmodium falciparum continues to be a major cause of disease and death in sub-Saharan Africa. 306 men aged 18-45 years were randomly assigned 3 doses of either RTS,S/AS02 or rabies vaccine (control). Volunteers were given sulfadoxine /pyrimethamine 2 weeks before dose 3, and kept...
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| Published in: | The Lancet (British edition) 2001-12, Vol.8, p.1927-1934 |
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| Main Authors: | , , , , , , , , , , , , , , , , , , |
| Format: | Article |
| Language: | English |
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| container_end_page | 1934 |
| container_issue | |
| container_start_page | 1927 |
| container_title | The Lancet (British edition) |
| container_volume | 8 |
| creator | Bojang, K A Milligan, P J M Pinder, M Vigneron, L Alloueche, A Kester, K E Ballou, W R Conway, D J Reece, W H H Gothard, P Yamuah, L Delchambre, M Voss, G Greenwood, B M Hill, A McAdam, K P W J Tornieporth, N Cohen, J D Doherty, T |
| description | Malaria caused by Plasmodium falciparum continues to be a major cause of disease and death in sub-Saharan Africa. 306 men aged 18-45 years were randomly assigned 3 doses of either RTS,S/AS02 or rabies vaccine (control). Volunteers were given sulfadoxine /pyrimethamine 2 weeks before dose 3, and kept under surveillance throughout the malaria transmission season. Blood smears were collected once a week and whenever a volunteer developed symptoms compatible with malaria. Found that RTS,S/AS02 is safe, immunogenic, and is the first pre-erythrocytic vaccine to show significant protection against natural Plasmodium falciparum infection. (Original abstract - amended) |
| format | article |
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| fulltext | fulltext |
| identifier | ISSN: 0140-6736 |
| ispartof | The Lancet (British edition), 2001-12, Vol.8, p.1927-1934 |
| issn | 0140-6736 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_57361354 |
| source | Applied Social Sciences Index & Abstracts (ASSIA); ScienceDirect Freedom Collection; BSC - Ebsco (Business Source Ultimate) |
| subjects | Efficacy Gambia Immunological status Malaria Men Randomized controlled trials Vaccines |
| title | Efficacy of RTS,S/AS02 malaria vaccine against Plasmodium falciparum infection in semi-immune adult men in the Gambia: a randomised trial |
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