Relationship between subjective effects and drug preferences: ethanol and diazepam

The relationship between subjective effects and drug preferences in normal volunteers was explored in a meta-analysis of several previously published studies. Subjective effects of, and preference for, ethanol and diazepam vs. placebo were measured using a choice procedure. Subjects were grouped acc...

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Bibliographic Details
Published in:Drug and alcohol dependence 1994-02, Vol.34 (3), p.243-251
Main Authors: Chutuape, Mary Ann D., De Wit, Harriet
Format: Article
Language:English
Subjects:
Addictive behaviors
Adult
Adult and adolescent clinical studies
Affect - drug effects
Alcohol Drinking - psychology
Alcoholic Intoxication - psychology
Arousal - drug effects
Biological and medical sciences
Choice Behavior
Diazepam
Dose-Response Relationship, Drug
Double-Blind Method
Drug abuse
Drug addiction
Drug Administration Schedule
Drug preference
Ethanol
Euphoria - drug effects
Female
Humans
Individual differences
Individuality
Male
Medical sciences
Personality Inventory
Preferences
Psychology. Psychoanalysis. Psychiatry
Psychopathology. Psychiatry
Subjective effects
Substance-Related Disorders - psychology
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Summary:The relationship between subjective effects and drug preferences in normal volunteers was explored in a meta-analysis of several previously published studies. Subjective effects of, and preference for, ethanol and diazepam vs. placebo were measured using a choice procedure. Subjects were grouped according to their drug choices: ‘non-choosers’ never chose drug, whereas ‘choosers’ always chose drug. The two groups were compared on their subjective responses to drug and on demographic variables. Ethanol decreased Arousal, Elation, Positive Mood and Vigor, and increased Anxiety, Depression and Fatigue in the non-choosers, whereas it increased Arousal and Vigor in the choosers. Ethanol choosers were also more likely to be males and/or full-time students than non-choosers. Diazepam produced sedative-like effects in both choosers and non-choosers, but markedly decreased Anxiety and increased Friendliness in choosers only. Diazepam choice was also associated with more frequent recreational use of marijuana and stimulants. Thus, both demographic variables and subjective drug effects were related to drug preference.
ISSN:0376-8716
1879-0046
DOI:10.1016/0376-8716(94)90163-5