Carbamazepine treatment for cocaine dependence

We report on a double-blind, placebo-controlled study of carbamazepine (CBZ) treatment for cocaine dependence. A previously reported uncontrolled study found CBZ to be a beneficial pharmacotherapy for cocaine dependence. Statistical analyses were performed on data from 82 subjects who were randomize...

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Bibliographic Details
Published in:Drug and alcohol dependence 1995-06, Vol.38 (3), p.221-227
Main Authors: Cornish, James W., Maany, Iraj, Fudala, Paul J., Neal, Sheryl, Poole, Sabrina A., Volpicelli, Patricia, O'Brien, Charles P.
Format: Article
Language:English
Subjects:
Addicts
Adult
Anticonvulsants - therapeutic use
Biological and medical sciences
Carbamazepine
Carbamazepine - therapeutic use
Cocaine
Cocaine - analogs & derivatives
Cocaine - pharmacokinetics
Cocaine dependence
Craving
Dose-Response Relationship, Drug
Double-Blind Method
Drug addictions
Drug Administration Schedule
Female
Humans
Kindling, Neurologic - drug effects
Male
Medical sciences
Middle Aged
Narcotics
Pharmacotherapy
Substance Abuse Detection
Substance-Related Disorders - psychology
Substance-Related Disorders - rehabilitation
Toxicology
Treatment
Treatment Outcome
Urinary benzoylecgonine
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Summary:We report on a double-blind, placebo-controlled study of carbamazepine (CBZ) treatment for cocaine dependence. A previously reported uncontrolled study found CBZ to be a beneficial pharmacotherapy for cocaine dependence. Statistical analyses were performed on data from 82 subjects who were randomized to 10 weeks' treatment with either CBZ, titrated to 4–12 μg/ml, ( n = 37) or placebo ( n = 45). The two treatment groups did not differ for primary outcome measures of retention time in treatment, urine samples positive for cocaine metabolite, subject reported desire for cocaine or for subject reported side-effects. CBZ was not an effective treatment in this study.
ISSN:0376-8716
1879-0046
DOI:10.1016/0376-8716(95)01102-5