Effects of marijuana history on the subjective, psychomotor, and reinforcing effects of nitrous oxide in humans

An experiment using marijuana users and non-users was conducted to assess whether the reinforcing, subjective, or psychomotor effects of nitrous oxide were influenced by a subject's drug history. Subjects in the first four sessions sampled 40% nitrous oxide in oxygen and 100% oxygen (placebo),...

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Bibliographic Details
Published in:Drug and alcohol dependence 1994-12, Vol.36 (3), p.227-236
Main Authors: Yajnik, Santosh, Thapar, Pankaj, Lichtor, J.Lance, Patterson, Todd, Zacny, James P.
Format: Article
Language:English
Subjects:
Abuse
Administration, Inhalation
Adult
Affect - drug effects
Arousal - drug effects
Attention - drug effects
Biological and medical sciences
Cannabis
Drug addictions
Factors
Female
History
Human
Humans
Male
Marijuana Abuse - psychology
Medical sciences
Motivation
Neuropsychological Tests
Nitrous oxide
Nitrous Oxide - pharmacology
Personality Inventory
Prior
Psychomotor Performance - drug effects
Reinforcer
Subjective effects
Toxicology
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Summary:An experiment using marijuana users and non-users was conducted to assess whether the reinforcing, subjective, or psychomotor effects of nitrous oxide were influenced by a subject's drug history. Subjects in the first four sessions sampled 40% nitrous oxide in oxygen and 100% oxygen (placebo), and then over the next three sessions, chose which agent they wished to inhale. Choice distributions between the two groups did not differ significantly, and nitrous oxide choice rates were less than 50% in both groups. However, a history of marijuana use appeared to intensify some of the subjective effects induced by nitrous oxide inhalation.
ISSN:0376-8716
1879-0046
DOI:10.1016/0376-8716(94)90149-X