Opiate detoxification of methadone maintenance patients using lefetamine, clonidine and buprenorphine

Thirty-nine methadone maintenance patients were included in a 9-day, double blind, randomized, inpatient detoxification trial. Methadone was tapered to 10 mg/day and then patients were assigned to one of these 3 protocols: clonidine (0.3-0.9 mgday), lefetamine (60–240 mg/day), buprenorphine (0.15-0....

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Bibliographic Details
Published in:Drug and alcohol dependence 1994-10, Vol.36 (2), p.139-145
Main Authors: Janiri, Luigi, Mannelli, Paolo, Persico, Antonio M., Serretti, Alessandro, Tempesta, Enrico
Format: Article
Language:English
Subjects:
Abusers
Adult
Analgesics, Opioid - administration & dosage
Analgesics, Opioid - adverse effects
Buprenorphine
Buprenorphine - administration & dosage
Buprenorphine - adverse effects
Clonidine
Clonidine - administration & dosage
Clonidine - adverse effects
Detoxification
Dose-Response Relationship, Drug
Double-Blind Method
Drug Administration Schedule
Female
Follow-Up Studies
Heroin Dependence - rehabilitation
Humans
Lefetamine
Male
Methadone
Methadone - administration & dosage
Methadone - adverse effects
Methadone detoxification
Neurologic Examination - drug effects
Opiates
Opioid-Related Disorders - rehabilitation
Patient Admission
Phenethylamines - administration & dosage
Phenethylamines - adverse effects
Substance Withdrawal Syndrome - rehabilitation
Treatment
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Summary:Thirty-nine methadone maintenance patients were included in a 9-day, double blind, randomized, inpatient detoxification trial. Methadone was tapered to 10 mg/day and then patients were assigned to one of these 3 protocols: clonidine (0.3-0.9 mgday), lefetamine (60–240 mg/day), buprenorphine (0.15-0.9 mg/day). Buprenorphine treatment was significantly superior to clonidine and to lefetamine ( F = 3.96 df = 2, 29 P < 0.05) in controlling objective, subjective and psychological withdrawal symptomatology. Clonidine was more effective than lefetamine in suppressing withdrawal in the first 3 days of treatment (day 3: F = 4.10 df = 2, 30 P < 0.05), and this trend was apparent on the objective and psychological items. In addition to evaluations of the efficacy of the single drugs used, the study showed that tapering methadone to low doses before entering the pharmacologically assisted discontinuation phase was clinically acceptable in detoxification from long-term methadone treatment.
ISSN:0376-8716
1879-0046
DOI:10.1016/0376-8716(94)90096-5