How do genes influence marijuana use? The role of subjective effects

This study investigated determinants of the subjective effects of marijuana and the relationship of subjective effects to marijuana use. Subjects were 8169 twins drawn from the Vietnam Era Twin Registry. Subjects who used marijuana more than five times (n= 2513) reported whether they experienced eac...

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Bibliographic Details
Published in:Addiction (Abingdon, England) England), 1997-04, Vol.92 (4), p.409-417
Main Authors: LYONS, MICHAEL J., TOOMEY, ROSEMARY, MEYER, JOANNE M., GREEN, ALAN I., EISEN, SETH A., GOLDBERG, JACK, TRUE, WILLIAM R., TSUANG, MING T.
Format: Article
Language:English
Subjects:
Abuse
Addictive behaviors
Adult
Adult and adolescent clinical studies
Biological and medical sciences
Cannabis
Diseases in Twins - genetics
Diseases in Twins - psychology
Drug addiction
Drug use
Drugs
Emotions
Environment
Environmental-Genetic factors
Genetics
Health
Human behaviour
Humans
Male
Marijuana Abuse - genetics
Marijuana Abuse - psychology
Medical sciences
Middle Aged
Psychology. Psychoanalysis. Psychiatry
Psychopathology. Psychiatry
Social problems
Time Factors
Twin studies
Twins
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Summary:This study investigated determinants of the subjective effects of marijuana and the relationship of subjective effects to marijuana use. Subjects were 8169 twins drawn from the Vietnam Era Twin Registry. Subjects who used marijuana more than five times (n= 2513) reported whether they experienced each of 23 subjective reactions. Factor analysis identified a positive (pleasant) reaction factor and a negative (unpleasant) reaction factor. Both factors were related to duration and frequency of use. Pairs in which both members used mariguana more than five times (MZ = 352 pairs; DZ = 255 pairs) were examined to assess determinants of subjective effects. Approximately one‐quarter of the variance in each factor was determined by additive genetic influences; the remaining variance was determined by environmental factors that are not shared by members of a twin pair. The shared or family environment had no detectable influence on either subjective reaction factor.
ISSN:0965-2140
1360-0443
DOI:10.1111/j.1360-0443.1997.tb03372.x