Dopamine receptor responsivity in alcoholic patients before and after detoxification

Objective: To assess central dopamine receptor responsivity in alcoholic patients during their usual alcohol consumption and after detoxification. Method: Plasma prolactin levels were measured at 0, 30, 60, and 90 min after administration of 5 mg haloperidol i.m. in 21 hospitalized male alcoholic pa...

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Bibliographic Details
Published in:Drug and alcohol dependence 2000, Vol.57 (3), p.261-265
Main Authors: Markianos, Manolis, Moussas, George, Lykouras, Lefteris, Hatzimanolis, John
Format: Article
Language:English
Subjects:
Adult
Alcoholic patients
Alcoholics
Alcoholism - physiopathology
Alcoholism - rehabilitation
Biological and medical sciences
Brain - physiopathology
Desintoxication. Drug withdrawal
Detoxification
Dopamine
Dopamine receptor responsivity
Ethanol - adverse effects
Haloperidol
Humans
Male
Medical sciences
Middle Aged
Prolactin - blood
Psychology. Psychoanalysis. Psychiatry
Psychopathology. Psychiatry
Receptors, Dopamine - physiology
Responsiveness
Substance Withdrawal Syndrome - physiopathology
Substance Withdrawal Syndrome - rehabilitation
Treatment
Treatments
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Summary:Objective: To assess central dopamine receptor responsivity in alcoholic patients during their usual alcohol consumption and after detoxification. Method: Plasma prolactin levels were measured at 0, 30, 60, and 90 min after administration of 5 mg haloperidol i.m. in 21 hospitalized male alcoholic patients during usual alcohol consumption, and 13 days later (mean, range 7–17 days), after detoxification. The test was also performed in seven healthy male volunteers. The patterns of prolactin responses were compared using repeated measures analysis of variance. Results: The prolactin responses to haloperidol increased significantly after detoxification compared to those during usual alcohol consumption (state×time interaction P
ISSN:0376-8716
1879-0046
DOI:10.1016/S0376-8716(99)00056-3