Double-blind randomized trial of buprenorphine and methadone in opiate dependence

This study compared the safety and efficacy of sublingual buprenorphine tablets with oral methadone in a population of opioid-dependent individuals in a double-blind, randomized, 6-week trial using a flexible dosing procedure. Fifty-eight patients seeking treatment for opioid dependence were recruit...

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Bibliographic Details
Published in:Drug and alcohol dependence 2001-03, Vol.62 (1), p.97-104
Main Authors: Petitjean, Sylvie, Stohler, Rudolf, Déglon, Jean-Jacques, Livoti, Santino, Waldvogel, Doris, Uehlinger, Claude, Ladewig, Dieter
Format: Article
Language:English
Subjects:
Adult
Analysis of Variance
Behavior, Addictive - psychology
Biological and medical sciences
Buprenorphine
Buprenorphine - therapeutic use
Buprenorphine tablet
Chi-Square Distribution
Controlled trial
Double blind randomized trials
Double-Blind Method
Drug addictions
Drug addicts
Female
Heroin Dependence - psychology
Heroin Dependence - rehabilitation
Heroin Dependence - urine
Humans
Male
Medical sciences
Methadone
Methadone - therapeutic use
Methadone maintenance
Narcotic Antagonists - therapeutic use
Opiates
Opioid-Related Disorders - psychology
Opioid-Related Disorders - rehabilitation
Opioid-Related Disorders - urine
Opioids
Patient Compliance
Toxicology
Treatment
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Summary:This study compared the safety and efficacy of sublingual buprenorphine tablets with oral methadone in a population of opioid-dependent individuals in a double-blind, randomized, 6-week trial using a flexible dosing procedure. Fifty-eight patients seeking treatment for opioid dependence were recruited in three outpatient facilities and randomly assigned to substitution with buprenorphine or methadone. The retention rate was significantly better in the methadone maintained group (90 vs. 56%; P
ISSN:0376-8716
1879-0046
DOI:10.1016/S0376-8716(00)00163-0