Genetic and environmental influences on drug use and abuse/dependence in male and female twins

Twins were recruited through alcohol and drug treatment programs. With structural equation modeling, genetic and environmental estimates were obtained for use and DSM-III abuse/dependence of sedatives, opioids, cocaine, stimulants, and cannabis as well as any illicit drug. Analyses were conducted se...

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Bibliographic Details
Published in:Drug and alcohol dependence 1998-11, Vol.52 (3), p.231-241
Main Authors: van den Bree, Marianne B.M, Johnson, Eric O, Neale, Michael C, Pickens, Roy W
Format: Article
Language:English
Subjects:
Addictive behaviors
Adolescent
Adult
Adult and adolescent clinical studies
Alcoholism - genetics
Alcoholism - psychology
Alcoholism - rehabilitation
Biological and medical sciences
Diseases in Twins - genetics
Diseases in Twins - psychology
Drug abuse
Drug abuse/dependence
Drug addiction
Drug dependency
Drug use
Environmental aspects
Female
Gender
Gender differences
Genetic and environmental influences
Genetic factors
Genetic Predisposition to Disease - genetics
Genetic Predisposition to Disease - psychology
Humans
Male
Medical sciences
Middle Aged
Minnesota
Psychology. Psychoanalysis. Psychiatry
Psychopathology. Psychiatry
Psychotropic Drugs
Risk Factors
Social Environment
Street Drugs
Substance-Related Disorders - genetics
Substance-Related Disorders - psychology
Substance-Related Disorders - rehabilitation
Twins
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Description
Summary:Twins were recruited through alcohol and drug treatment programs. With structural equation modeling, genetic and environmental estimates were obtained for use and DSM-III abuse/dependence of sedatives, opioids, cocaine, stimulants, and cannabis as well as any illicit drug. Analyses were conducted separately for males and females. Models included thresholds based on population prevalence of use or abuse/dependence and ever having been in treatment. Genetic influences were found for most measures. They were generally stronger for males than females and for clinical diagnoses of abuse/dependence compared to use. Common environmental influences played a greater role in use than abuse/dependence.
ISSN:0376-8716
1879-0046
DOI:10.1016/S0376-8716(98)00101-X