REPLICATIVE SENESCENCE CAN BE MODULATED BY ALTERATIONS IN NUCLEAR MAP KINASE ACTIVITY

An abstract of a study by Tresini et al investigating the biological significance and the mechanism underlying the decreased abundance of active ERK in senescent cell nuclei is presented. Results suggest that impairments of the ERK signalling pathway are in part responsible for the senescent phenoty...

Full description

Saved in:
Bibliographic Details
Published in:The Gerontologist 2004-10, Vol.44 (1), p.14-14
Main Authors: Tresini, M, Torres, C, Cristofalo, V, Lorenzini, A
Format: Article
Language:English
Subjects:
Aging
Cell culture
Enzymes
Genotype & phenotype
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:An abstract of a study by Tresini et al investigating the biological significance and the mechanism underlying the decreased abundance of active ERK in senescent cell nuclei is presented. Results suggest that impairments of the ERK signalling pathway are in part responsible for the senescent phenotype and support the hypothesis that restoration of nuclear ERK2 activity can temporarily prevent the onset of senescence.
ISSN:0016-9013
1758-5341