Anti-angiogenesis and anti-tumor effects of AdNT4-anginex

Abstract Anginex is a novel artificial peptide that can inhibit angiogenesis. AdNT4-anginex was constructed by inserting the artificial anginex gene into a recombinant adenoviral vector. We demonstrated that AdNT4-anginex inhibited migration of human endothelial cells, angiogenesis and tumor growth...

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Bibliographic Details
Published in:Cancer letters 2009-11, Vol.285 (2), p.218-224
Main Authors: Dong, Dan Feng, Li, En Xiao, Wang, Ju Bo, Wu, Yin Ying, Shi, Fan, Guo, Jun Jun, Wu, Yuan, Liu, Jun Ping, Liu, Shan Xi, Yang, Guang Xiao
Format: Article
Language:English
Subjects:
Adenoviridae - genetics
Anginex
Angiogenesis
Animals
Anti-angiogenesis
Antineoplastic Agents - pharmacology
Cell Line, Tumor
Cell Movement - drug effects
Chick Embryo
Colleges & universities
Female
Genetic Vectors
Hematology, Oncology and Palliative Medicine
Humans
Mice
Migration
Neovascularization, Pathologic - drug therapy
Peptide
Peptides
Proteins - pharmacology
Recombinant adenovirus
Rodents
Tumors
Vascular endothelial growth factor
Xenograft Model Antitumor Assays
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Summary:Abstract Anginex is a novel artificial peptide that can inhibit angiogenesis. AdNT4-anginex was constructed by inserting the artificial anginex gene into a recombinant adenoviral vector. We demonstrated that AdNT4-anginex inhibited migration of human endothelial cells, angiogenesis and tumor growth in in vitro and in vivo studies. Tumor growth of human H22 hepatoma in mice was inhibited after AdNT4-anginex treatment for 4 weeks, and a significant decrease in tumor size was observed as compared with the control group. Overall, these studies indicate that AdNT4-anginex is an effective anti-tumor agent, and deserves more attention and research.
ISSN:0304-3835
1872-7980
DOI:10.1016/j.canlet.2009.05.021