Obesity is an important determinant of baseline serum C-reactive protein concentration in monozygotic twins, independent of genetic influences

C-reactive protein (CRP) values predict atherothrombotic cardiovascular disease and type 2 diabetes mellitus. Associations between CRP and obesity, predominantly assessed anthropometrically, may partly explain these observations. Previous studies have been unable to control for genetic influences on...

Full description

Saved in:
Bibliographic Details
Published in:Circulation (New York, N.Y.) N.Y.), 2004-06, Vol.109 (24), p.3022-3028
Main Authors: GREENFIELD, Jerry R, SAMARAS, Katherine, JENKINS, Arthur B, KELLY, Paul J, SPECTOR, Tim D, GALLIMORE, J. Ruth, PEPYS, Mark B, CAMPBELL, Lesley V
Format: Article
Language:English
Subjects:
Abdomen
Absorptiometry, Photon
Adipose Tissue - pathology
Adult
Aged
Alcohol Drinking - blood
Apolipoproteins - analysis
Arteriosclerosis - genetics
Associated diseases and complications
Australia - epidemiology
Biological and medical sciences
Blood and lymphatic vessels
Blood Pressure
C-Reactive Protein - analysis
Cardiology. Vascular system
Cohort Studies
Coronary Disease - genetics
Diabetes Mellitus, Type 2 - genetics
Diabetes. Impaired glucose tolerance
Diseases in Twins - blood
Diseases in Twins - genetics
Diseases of the peripheral vessels. Diseases of the vena cava. Miscellaneous
Endocrine pancreas. Apud cells (diseases)
Endocrinopathies
England - epidemiology
Female
Genetic Predisposition to Disease
Hormone Replacement Therapy
Humans
Lipids - blood
Medical sciences
Metabolic Syndrome - genetics
Middle Aged
Neurology
Obesity - blood
Obesity - diagnostic imaging
Postmenopause - blood
Smoking - blood
Somatotypes
Twins, Monozygotic
Vascular diseases and vascular malformations of the nervous system
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:C-reactive protein (CRP) values predict atherothrombotic cardiovascular disease and type 2 diabetes mellitus. Associations between CRP and obesity, predominantly assessed anthropometrically, may partly explain these observations. Previous studies have been unable to control for genetic influences on CRP and obesity. The aim of this study was to examine the relationship between CRP and accurately measured body fat, lipids, apolipoproteins, blood pressure, and environmental and behavioral factors, independent of genetic influences. One hundred ninety-four healthy female twins (age 57.2+/-7 years) were studied after excluding pairs with CRP values >10 mg/L. Total body fat and central abdominal fat (CAF) were measured by dual-energy x-ray absorptiometry. CRP concentration was strongly related to surrogate and direct measures of body fat (r=0.31 to 0.54, P
ISSN:0009-7322
1524-4539
DOI:10.1161/01.cir.0000130640.77501.79