Interstrand communication between 2'-N-(pyren-1-yl)methyl-2'-amino-LNA monomers in nucleic acid duplexes: directional control and signalling of full complementarity

Very efficient interstrand communication systems in nucleic acid duplexes, based on pyrene excimer formation between 2'-N-(pyren-1-yl)methyl-2'-amino-LNA monomers, demonstrate the versatility of functionalized 2'-amino-LNA monomers for Angstrom-scale chemical engineering.

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Bibliographic Details
Published in:Chemical communications (Cambridge, England) England), 2004-07 (13), p.1478-1479
Main Authors: Hrdlicka, Patrick J, Babu, B Ravindra, Sørensen, Mads D, Wengel, Jesper
Format: Article
Language:English
Subjects:
Base Pair Mismatch
Chemical Engineering - methods
DNA Probes
DNA, Complementary - chemistry
Hot Temperature
Molecular Structure
Nucleic Acid Conformation
Nucleic Acid Denaturation
Nucleic Acids - chemistry
Oligonucleotides
Oligonucleotides, Antisense - chemistry
Pyrenes - chemistry
Spectrometry, Fluorescence
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Summary:Very efficient interstrand communication systems in nucleic acid duplexes, based on pyrene excimer formation between 2'-N-(pyren-1-yl)methyl-2'-amino-LNA monomers, demonstrate the versatility of functionalized 2'-amino-LNA monomers for Angstrom-scale chemical engineering.
ISSN:1359-7345
1364-548X
DOI:10.1039/b404446k