Zinc-proline catalyzed pathway for the formation of sugars

Zn-proline catalyzes the aldolisation of unprotected glycolaldehyde in water to give tetroses and hexoses; threose (33% of the product mixture) was formed with 10% enantiomeric excess of the D-isomer.

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Bibliographic Details
Published in:Chemical communications (Cambridge, England) England), 2004-07 (13), p.1540-1541
Main Authors: Kofoed, Jacob, Machuqueiro, Miguel, Reymond, Jean-Louis, Darbre, Tamis
Format: Article
Language:English
Subjects:
Acetaldehyde - analogs & derivatives
Acetaldehyde - chemistry
Carbohydrates - chemical synthesis
Catalysis
Hexoses - chemical synthesis
Molecular Structure
Proline - chemistry
Solutions
Stereoisomerism
Tetroses - chemical synthesis
Zinc - chemistry
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Description
Summary:Zn-proline catalyzes the aldolisation of unprotected glycolaldehyde in water to give tetroses and hexoses; threose (33% of the product mixture) was formed with 10% enantiomeric excess of the D-isomer.
ISSN:1359-7345
1364-548X
DOI:10.1039/b404465g