Thermal characterization of poly(ethylene glycol)–poly( d, l-lactide) block copolymer micelles based on pyrene excimer formation

Poly(ethylene glycol)–poly( d, l-lactide) (PEG–PDLLA) block copolymers were prepared by anionic ring-opening polymerization, resulting in block sizes effectively controlled by initial monomer/initiator ratios and low molecular weight distributions (95%. The so-obtained PEG–PDLLA–Py copolymers displa...

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Bibliographic Details
Published in:Journal of controlled release 2004-07, Vol.97 (3), p.407-419
Main Authors: Jule, Eduardo, Yamamoto, Yuji, Thouvenin, Muriel, Nagasaki, Yukio, Kataoka, Kazunori
Format: Article
Language:English
Subjects:
Acetal–poly(ethylene glycol)–poly( d, l-lactide) (PEG–PDLLA) block copolymers
Biological and medical sciences
Chain exchange
General pharmacology
Lactates - chemistry
Lactates - pharmacokinetics
Medical sciences
Micelles
Pharmaceutical technology. Pharmaceutical industry
Pharmacology. Drug treatments
Polyethylene Glycols - chemistry
Polyethylene Glycols - pharmacokinetics
Polymeric micelles
Pyrene excimer formation
Pyrenes - chemistry
Pyrenes - pharmacokinetics
Temperature
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Summary:Poly(ethylene glycol)–poly( d, l-lactide) (PEG–PDLLA) block copolymers were prepared by anionic ring-opening polymerization, resulting in block sizes effectively controlled by initial monomer/initiator ratios and low molecular weight distributions (95%. The so-obtained PEG–PDLLA–Py copolymers displayed fluorescent properties that were associated with the pyrene monomers, when placed in good solvents for both the hydrophilic and hydrophobic blocks. When placed in selective solvents, these copolymers self-assembled into micelles in the 30-nm range, also with low particle size distributions (
ISSN:0168-3659
1873-4995
DOI:10.1016/j.jconrel.2004.02.012