Molecular Imprinting Made Easy

A simple method of molecular imprinting is presented that uses a single cross-linking monomer N,O-bismethacryloyl ethanolamine (NOBE) along with template, initiator, and solvent. This formulation eliminates the need for additional functional monomers and empirical optimization of relative ratios of...

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Bibliographic Details
Published in:Journal of the American Chemical Society 2004-06, Vol.126 (25), p.7827-7833
Main Authors: Sibrian-Vazquez, Martha, Spivak, David A
Format: Article
Language:English
Subjects:
Analytical chemistry
Binding Sites
Chemistry
Chromatography, High Pressure Liquid
Cross-Linking Reagents - chemistry
Ethanolamine - chemistry
Exact sciences and technology
General, instrumentation
Methacrylates - chemistry
Molecular Structure
Naphthols - chemistry
Polymers - chemistry
Solvents - chemistry
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Summary:A simple method of molecular imprinting is presented that uses a single cross-linking monomer N,O-bismethacryloyl ethanolamine (NOBE) along with template, initiator, and solvent. This formulation eliminates the need for additional functional monomers and empirical optimization of relative ratios of functional monomers, cross-linkers, and template. In fact, utilization of NOBE alone often provides molecularly imprinted polymers (MIPs) with higher performance than MIPs incorporating functional monomer (e.g., methacrylic acid).
ISSN:0002-7863
1520-5126
DOI:10.1021/ja038961b