Variation in the Shiga Toxin Region of 20th-Century Epidemic and Endemic Shigella dysenteriae 1 Strains

The Shiga toxin (Stx) region of Shigella dysenteriae 1 lies on a defective prophage homologous to lambdoidbacteriophages in Stx-producing Escherichia coli. S. dysenteriae 1 strains obtained in locations throughout the world over the course of the past 60 years were assessed for variations in the Stx...

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Bibliographic Details
Published in:The Journal of infectious diseases 2004-07, Vol.190 (2), p.330-334
Main Authors: Greco, Karla M., McDonough, Marie A., Butterton, Joan R.
Format: Article
Language:English
Subjects:
Bacteria
Bacteriology
Bacteriophages
Biological and medical sciences
Defective Viruses - genetics
DNA Transposable Elements
DNA, Bacterial - chemistry
DNA, Bacterial - isolation & purification
Dysentery, Bacillary - epidemiology
Dysentery, Bacillary - microbiology
Escherichia coli
Escherichia coli O157
Fundamental and applied biological sciences. Psychology
Gene Order
Genes
Genes, Bacterial
Humans
Infectious diseases
Lysogeny - genetics
Medical sciences
Microbiology
Miscellaneous
Molecular Epidemiology
Molecular Sequence Data
Polymerase Chain Reaction
Prophages
Prophages - genetics
Sequence Analysis, DNA
Shiga Toxin - genetics
Shiga toxins
Shigella
Shigella dysenteriae
Shigella dysenteriae - genetics
Shigella dysenteriae - isolation & purification
Shigella dysenteriae - virology
Siphoviridae - genetics
Toxins
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Summary:The Shiga toxin (Stx) region of Shigella dysenteriae 1 lies on a defective prophage homologous to lambdoidbacteriophages in Stx-producing Escherichia coli. S. dysenteriae 1 strains obtained in locations throughout the world over the course of the past 60 years were assessed for variations in the Stx region by use of polymerase chain reaction and sequence analysis. The defective prophage was present in all strains examined, suggesting that all S. dysenteriae 1 isolates derive from a clone that resulted from a single phage-integration event. All western-hemisphere strains have an additional iso-IS1 insertion element upstream of stxAB, implying that there has been minimal exchange of strains between hemispheres in recent decades.
ISSN:0022-1899
1537-6613
DOI:10.1086/421706