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Advanced pancreatic carcinoma showing a complete response to arterial infusion chemotherapy
We report a patient with advanced carcinoma of the pancreatic body and tail with multiple liver metastases who showed a complete response to hepatic and splenic arterial infusion chemotherapy (HSAIC) with gemcitabine and 5-fluorouracil, following transcatheter peripancreatic arterial embolization (T...
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| Published in: | International journal of clinical oncology 2004-06, Vol.9 (3), p.197-201 |
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| Main Authors: | , , , , , , , , , |
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| container_end_page | 201 |
| container_issue | 3 |
| container_start_page | 197 |
| container_title | International journal of clinical oncology |
| container_volume | 9 |
| creator | Homma, Hisato Akiyama, Takehide Mezawa, Shinichi Doi, Tadashi Takanashi, Kunihiro Machida, Takuro Murakami, Ken Katsuki, Shinichi Sato, Tsutomu Hirata, Kenichiro |
| description | We report a patient with advanced carcinoma of the pancreatic body and tail with multiple liver metastases who showed a complete response to hepatic and splenic arterial infusion chemotherapy (HSAIC) with gemcitabine and 5-fluorouracil, following transcatheter peripancreatic arterial embolization (TPPAE) and partial splenic embolization (PSE). Nonresectable advanced pancreatic carcinoma tends to have a low response to medical treatment, with the median survival time being 6 months or less for stage IV cases. We disclose herein that the median survival time of patients receiving HSAIC after TPPAE is more than three times longer than the survival time attained with conventional treatments. However, in patients with advanced carcinoma of the pancreatic tail, for which TTPAE is not applicable, survival times remain low. Thus, in the patient described here, we also performed embolization of the left gastric and short gastric arteries as well as PSE to increase the flow within the great pancreatic and caudal pancreatic arteries via the splenic artery, and gemcitabine and 5-fluorouracil were administered via the splenic artery. As a result of these procedures, marked reduction in the advanced carcinoma of the pancreatic body and tail and of liver metastases was attained. |
| doi_str_mv | 10.1007/s10147-004-0388-2 |
| format | article |
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Nonresectable advanced pancreatic carcinoma tends to have a low response to medical treatment, with the median survival time being 6 months or less for stage IV cases. We disclose herein that the median survival time of patients receiving HSAIC after TPPAE is more than three times longer than the survival time attained with conventional treatments. However, in patients with advanced carcinoma of the pancreatic tail, for which TTPAE is not applicable, survival times remain low. Thus, in the patient described here, we also performed embolization of the left gastric and short gastric arteries as well as PSE to increase the flow within the great pancreatic and caudal pancreatic arteries via the splenic artery, and gemcitabine and 5-fluorouracil were administered via the splenic artery. As a result of these procedures, marked reduction in the advanced carcinoma of the pancreatic body and tail and of liver metastases was attained.</description><identifier>ISSN: 1341-9625</identifier><identifier>EISSN: 1437-7772</identifier><identifier>DOI: 10.1007/s10147-004-0388-2</identifier><identifier>PMID: 15221606</identifier><language>eng</language><publisher>Japan: Springer Nature B.V</publisher><subject>Adenocarcinoma - blood supply ; Adenocarcinoma - mortality ; Adenocarcinoma - pathology ; Adenocarcinoma - therapy ; Adult ; Antineoplastic Combined Chemotherapy Protocols - administration & dosage ; Chemoembolization, Therapeutic ; Chemotherapy ; Deoxycytidine - administration & dosage ; Deoxycytidine - analogs & derivatives ; Drug therapy ; Fluorouracil - administration & dosage ; Humans ; Infusions, Intra-Arterial ; Liver Neoplasms - blood supply ; Liver Neoplasms - secondary ; Male ; Metastasis ; Pancreas ; Pancreatic cancer ; Pancreatic Neoplasms - blood supply ; Pancreatic Neoplasms - mortality ; Pancreatic Neoplasms - pathology ; Pancreatic Neoplasms - therapy ; Veins & arteries</subject><ispartof>International journal of clinical oncology, 2004-06, Vol.9 (3), p.197-201</ispartof><rights>Springer-Verlag Tokyo 2004</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c359t-49b605c0b50bc263792c0cccdfc7eab78d3dddd379d8bcd80aa28394c511544e3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/15221606$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Homma, Hisato</creatorcontrib><creatorcontrib>Akiyama, Takehide</creatorcontrib><creatorcontrib>Mezawa, Shinichi</creatorcontrib><creatorcontrib>Doi, Tadashi</creatorcontrib><creatorcontrib>Takanashi, Kunihiro</creatorcontrib><creatorcontrib>Machida, Takuro</creatorcontrib><creatorcontrib>Murakami, Ken</creatorcontrib><creatorcontrib>Katsuki, Shinichi</creatorcontrib><creatorcontrib>Sato, Tsutomu</creatorcontrib><creatorcontrib>Hirata, Kenichiro</creatorcontrib><title>Advanced pancreatic carcinoma showing a complete response to arterial infusion chemotherapy</title><title>International journal of clinical oncology</title><addtitle>Int J Clin Oncol</addtitle><description>We report a patient with advanced carcinoma of the pancreatic body and tail with multiple liver metastases who showed a complete response to hepatic and splenic arterial infusion chemotherapy (HSAIC) with gemcitabine and 5-fluorouracil, following transcatheter peripancreatic arterial embolization (TPPAE) and partial splenic embolization (PSE). Nonresectable advanced pancreatic carcinoma tends to have a low response to medical treatment, with the median survival time being 6 months or less for stage IV cases. We disclose herein that the median survival time of patients receiving HSAIC after TPPAE is more than three times longer than the survival time attained with conventional treatments. However, in patients with advanced carcinoma of the pancreatic tail, for which TTPAE is not applicable, survival times remain low. Thus, in the patient described here, we also performed embolization of the left gastric and short gastric arteries as well as PSE to increase the flow within the great pancreatic and caudal pancreatic arteries via the splenic artery, and gemcitabine and 5-fluorouracil were administered via the splenic artery. 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blood supply</subject><subject>Pancreatic Neoplasms - mortality</subject><subject>Pancreatic Neoplasms - pathology</subject><subject>Pancreatic Neoplasms - therapy</subject><subject>Veins & arteries</subject><issn>1341-9625</issn><issn>1437-7772</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2004</creationdate><recordtype>article</recordtype><recordid>eNpdkEtr3EAQhAdjYztOfkAuZiCQm-Ket3Q0xnmAIZf45MMwavVmZSSNPCPF7L_3LLsQcF-qaaqK5mPss4BvAsDdZAFCuwpAV6DqupIn7FJo5SrnnDwtu9Kiaqw0F-xDzs8Awlkjz9mFMFIKC_aSPd12_8KE1PG5SKKw9MgxJOynOAaet_G1n_7ywDGO80AL8UR5jlMmvkQe0kKpDwPvp82a-zhx3NIYly2lMO8-srNNGDJ9OuoVe_x-_-fuZ_Xw-8evu9uHCpVplko3rQWD0BpoUVrlGomAiN0GHYXW1Z3qypR7V7fY1RCCrFWj0QhhtCZ1xb4eeucUX1bKix_7jDQMYaK4Zm-tNXWjoRi_vDM-xzVN5TcvjAItoFQWlzi4MMWcE238nPoxpJ0X4Pfc_YG7L9z9nruXJXN9bF7bkbr_iSNo9QaSLX8R</recordid><startdate>200406</startdate><enddate>200406</enddate><creator>Homma, Hisato</creator><creator>Akiyama, Takehide</creator><creator>Mezawa, Shinichi</creator><creator>Doi, Tadashi</creator><creator>Takanashi, Kunihiro</creator><creator>Machida, Takuro</creator><creator>Murakami, Ken</creator><creator>Katsuki, Shinichi</creator><creator>Sato, Tsutomu</creator><creator>Hirata, Kenichiro</creator><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7TO</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>H94</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>M2O</scope><scope>MBDVC</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>Q9U</scope><scope>7X8</scope></search><sort><creationdate>200406</creationdate><title>Advanced pancreatic carcinoma showing a complete response to arterial infusion chemotherapy</title><author>Homma, Hisato ; Akiyama, Takehide ; Mezawa, Shinichi ; Doi, Tadashi ; Takanashi, Kunihiro ; Machida, Takuro ; Murakami, Ken ; Katsuki, Shinichi ; Sato, Tsutomu ; Hirata, Kenichiro</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c359t-49b605c0b50bc263792c0cccdfc7eab78d3dddd379d8bcd80aa28394c511544e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2004</creationdate><topic>Adenocarcinoma - 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Academic</collection><jtitle>International journal of clinical oncology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Homma, Hisato</au><au>Akiyama, Takehide</au><au>Mezawa, Shinichi</au><au>Doi, Tadashi</au><au>Takanashi, Kunihiro</au><au>Machida, Takuro</au><au>Murakami, Ken</au><au>Katsuki, Shinichi</au><au>Sato, Tsutomu</au><au>Hirata, Kenichiro</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Advanced pancreatic carcinoma showing a complete response to arterial infusion chemotherapy</atitle><jtitle>International journal of clinical oncology</jtitle><addtitle>Int J Clin Oncol</addtitle><date>2004-06</date><risdate>2004</risdate><volume>9</volume><issue>3</issue><spage>197</spage><epage>201</epage><pages>197-201</pages><issn>1341-9625</issn><eissn>1437-7772</eissn><abstract>We report a patient with advanced carcinoma of the pancreatic body and tail with multiple liver metastases who showed a complete response to hepatic and splenic arterial infusion chemotherapy (HSAIC) with gemcitabine and 5-fluorouracil, following transcatheter peripancreatic arterial embolization (TPPAE) and partial splenic embolization (PSE). Nonresectable advanced pancreatic carcinoma tends to have a low response to medical treatment, with the median survival time being 6 months or less for stage IV cases. We disclose herein that the median survival time of patients receiving HSAIC after TPPAE is more than three times longer than the survival time attained with conventional treatments. However, in patients with advanced carcinoma of the pancreatic tail, for which TTPAE is not applicable, survival times remain low. Thus, in the patient described here, we also performed embolization of the left gastric and short gastric arteries as well as PSE to increase the flow within the great pancreatic and caudal pancreatic arteries via the splenic artery, and gemcitabine and 5-fluorouracil were administered via the splenic artery. As a result of these procedures, marked reduction in the advanced carcinoma of the pancreatic body and tail and of liver metastases was attained.</abstract><cop>Japan</cop><pub>Springer Nature B.V</pub><pmid>15221606</pmid><doi>10.1007/s10147-004-0388-2</doi><tpages>5</tpages></addata></record> |
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| ispartof | International journal of clinical oncology, 2004-06, Vol.9 (3), p.197-201 |
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| subjects | Adenocarcinoma - blood supply Adenocarcinoma - mortality Adenocarcinoma - pathology Adenocarcinoma - therapy Adult Antineoplastic Combined Chemotherapy Protocols - administration & dosage Chemoembolization, Therapeutic Chemotherapy Deoxycytidine - administration & dosage Deoxycytidine - analogs & derivatives Drug therapy Fluorouracil - administration & dosage Humans Infusions, Intra-Arterial Liver Neoplasms - blood supply Liver Neoplasms - secondary Male Metastasis Pancreas Pancreatic cancer Pancreatic Neoplasms - blood supply Pancreatic Neoplasms - mortality Pancreatic Neoplasms - pathology Pancreatic Neoplasms - therapy Veins & arteries |
| title | Advanced pancreatic carcinoma showing a complete response to arterial infusion chemotherapy |
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