Usefulness of Rapid Quantitative Measurement of Myoglobin and Troponin T in Early Diagnosis of Acute Myocardial Infarction

Background New equipment, the Cardiac ReaderTM, which can measure blood concentrations of troponin T (T) and myoglobin (M) in only 15 min at the bedside was evaluated for early diagnosis of acute myocardial infarction (AMI). Methods and Results A total of 34 consecutive patients with AMI who came to...

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Bibliographic Details
Published in:Circulation Journal 2004, Vol.68(7), pp.639-644
Main Authors: Yamamoto, Masashi, Komiyama, Nobuyuki, Koizumi, Tomomi, Nameki, Mizuo, Yamamoto, Yutaka, Toyoda, Tomohiko, Okuno, Tomonobu, Tateno, Kaoru, Sano, Kouichi, Himi, Toshiharu, Kuriyama, Nehiro, Namikawa, Susumu, Yokoyama, Masaki, Komuro, Issei
Format: Article
Language:English
Subjects:
Acute myocardial infarction
Adult
Aged
Aged, 80 and over
Biomarkers - blood
Chest Pain - blood
Creatine Kinase - blood
Creatine Kinase, MB Form
Early diagnosis
Female
Humans
Isoenzymes - blood
Male
Middle Aged
Myocardial Infarction - blood
Myocardial Infarction - diagnosis
Myoglobin
Myoglobin - blood
Reproducibility of Results
Time Factors
Troponin T
Troponin T - blood
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Summary:Background New equipment, the Cardiac ReaderTM, which can measure blood concentrations of troponin T (T) and myoglobin (M) in only 15 min at the bedside was evaluated for early diagnosis of acute myocardial infarction (AMI). Methods and Results A total of 34 consecutive patients with AMI who came to hospital within 24 h after onset were studied. Blood samples were collected from the patients at admission and 6, 12, 24, 48 h after onset to qualitatively and quantitatively measure T, M and creatine kinase-MB fraction. There were 20 patients with positive results by qualitative troponin T test and 29 with positive results by quantitative test. Of the patients who visited hospital within 3 h of onset, 17% were positive by the qualitative test and 67% cases had positive results in the quantitative test. The patients were divided into 2 groups according to the flow grade in the infarct-related coronary artery. In the TIMI 0-1 group (n=28), serum myoglobin concentrations were higher than in the TIMI 3-4 group (n=6) at admission and at their peak. Conclusion The rapid quantitative test of T and M is useful for early diagnosis of AMI and as an indicator of its severity, which can be evaluated from the myoglobin concentration in the hyper-acute phase. (Circ J 2004; 68: 639 - 644)
ISSN:1346-9843
1347-4820
DOI:10.1253/circj.68.639