Comparison of nebulized magnesium sulfate plus albuterol to nebulized albuterol plus saline in children with acute exacerbations of mild to moderate asthma

A prospective, randomized, double blinded study was conducted to determine whether a combination of nebulized magnesium sulfate and albuterol as a single dose adds any benefit in management of children with mild to moderate asthma when compared to nebulized albuterol with saline. The difference in F...

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Bibliographic Details
Published in:The Journal of emergency medicine 2004-07, Vol.27 (1), p.21-25
Main Authors: Mahajan, Prashant, Haritos, Demetris, Rosenberg, Norman, Thomas, Ronald
Format: Article
Language:English
Subjects:
Acute Disease
Administration, Inhalation
Adolescent
Albuterol - administration & dosage
asthma
Asthma - classification
Asthma - drug therapy
Bronchodilator Agents - administration & dosage
Calcium Channel Blockers - administration & dosage
Child
Child, Preschool
Double-Blind Method
Drug Combinations
Female
Forced Expiratory Volume - drug effects
Humans
Magnesium Sulfate - administration & dosage
Male
nebulized magnesium sulfate
Nebulizers and Vaporizers
Prospective Studies
Sodium Chloride - administration & dosage
Treatment Outcome
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Summary:A prospective, randomized, double blinded study was conducted to determine whether a combination of nebulized magnesium sulfate and albuterol as a single dose adds any benefit in management of children with mild to moderate asthma when compared to nebulized albuterol with saline. The difference in FEV1 was significant at 10 and 20 min after a single dose of the combined treatment with magnesium and albuterol when compared with the albuterol and saline group (1.41 L ± 0.53 vs. 1.13 L ± 0.34, respectively, p = 0.03). The addition of magnesium to albuterol seems to provide short-term benefits in children with acute exacerbations of mild to moderate asthma.
ISSN:0736-4679
2352-5029
DOI:10.1016/j.jemermed.2004.02.006