Hormone and metabolic factors associated with leptin mRNA expression in pre- and postmenopausal women

Recent information has extended leptin’s action, beyond the control of appetite, to various sites of metabolic regulation. To better understand leptin’s role we studied its production in subcutaneous and visceral fat compartments before and after menopause. During elective abdominal surgery, biopsie...

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Bibliographic Details
Published in:Steroids 2004-06, Vol.69 (6), p.425-430
Main Authors: Fajardo, Martha E, Malacara, Juan M, Martı́nez-Rodrı́guez, Herminia G, Barrera-Saldaña, Hugo A
Format: Article
Language:English
Subjects:
Adipose tissue
Adipose Tissue - metabolism
Adult
Aged
Biological and medical sciences
Body Mass Index
Estradiol - blood
Estrogens
Female
Fundamental and applied biological sciences. Psychology
Glucose - metabolism
Hormones - blood
Humans
Leptin
Leptin - blood
Leptin - genetics
Leptin mRNA
Menopause
Middle Aged
Postmenopause - blood
Postmenopause - genetics
Postmenopause - metabolism
Premenopause - blood
Premenopause - genetics
Premenopause - metabolism
RNA, Messenger - genetics
RNA, Messenger - metabolism
Vertebrates: endocrinology
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Summary:Recent information has extended leptin’s action, beyond the control of appetite, to various sites of metabolic regulation. To better understand leptin’s role we studied its production in subcutaneous and visceral fat compartments before and after menopause. During elective abdominal surgery, biopsies of subcutaneous and omental tissues were taken from 20 women at pre- (BMI 28.4±4.5kg/m2) and 10 at postmenopause (BMI 30.6±7.7kg/m2). In both groups serum leptin levels were similar, and highly correlated with BMI. In subcutaneous adipose tissue, leptin mRNA expression was significantly higher in pre- than in postmenopausal women (50.4±20.5amol/μg total RNA versus 34.5±24.9amol/μg total RNA, respectively). Leptin mRNA expression in subcutaneous tissue was independently correlated with fasting glucose (R=0.89, P
ISSN:0039-128X
1878-5867
DOI:10.1016/j.steroids.2004.03.013