The HBP1 transcriptional repressor and the p38 MAP kinase: unlikely partners in G1 regulation and tumor suppression

Mechanisms that inhibit cell cycle progression and establish growth arrest are fundamental to tumor suppression and to normal cell differentiation. A complete understanding of these mechanisms should provide new diagnostic and therapeutic targets for future clinical applications related to cancer-sp...

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Bibliographic Details
Published in:Gene 2004-07, Vol.336 (1), p.1-13
Main Authors: Yee, Amy S., Paulson, Eric K., McDevitt, Michael A., Rieger-Christ, Kimberly, Summerhayes, Ian, Berasi, Stephen P., Kim, Jiyoung, Huang, Chun-Yin, Zhang, Xiaowei
Format: Article
Language:English
Subjects:
Amino Acid Sequence
Animals
Ataxin homology domain
AXH
Chromosome 7
G1 Phase - genetics
G1 Phase - physiology
HBP1
HDAC
High Mobility Group Proteins - genetics
High Mobility Group Proteins - physiology
Humans
Mitogen-Activated Protein Kinases - metabolism
Models, Biological
Molecular Sequence Data
Neoplasms - genetics
Neoplasms - physiopathology
p38 MAPK
p38 Mitogen-Activated Protein Kinases
p47 phox
Proto-Oncogene Proteins - metabolism
Repressor Proteins - genetics
Repressor Proteins - physiology
ROS
Sequence Homology, Amino Acid
Signal Transduction
Tumor suppressor
Wnt Proteins
Wnt signaling
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Summary:Mechanisms that inhibit cell cycle progression and establish growth arrest are fundamental to tumor suppression and to normal cell differentiation. A complete understanding of these mechanisms should provide new diagnostic and therapeutic targets for future clinical applications related to cancer-specific pathways. This review will focus on the HMG-box protein 1 (HBP1) transcriptional repressor and its roles in cell cycle progression and tumor suppression. The work of several labs now suggests a new pathway for inhibiting G1 progression with exciting possible implications for tumor suppression. Our recent work suggests that the two previously unassociated proteins—the HBP1 transcription factor and the p38 MAP kinase pathway—may now participate together in a G1 regulatory network. Several recent papers collectively highlight an unexpected role and connection of the p38 MAP kinase-signaling pathway in cell cycle control, senescence, and tumor suppression. Together, these initially divergent observations may provide clues into a new tumor suppressive network and spur further investigations that may contribute to new diagnostic and therapeutic targets for cancer.
ISSN:0378-1119
1879-0038
DOI:10.1016/j.gene.2004.04.004