Bionanotechnology based on silica nanoparticles

We have developed uniform core/shell nanoparticles, consisting of a silica layer coating and pigments or magnetite core, using a water‐in‐oil microemulsion method. The nanoparticles are highly luminescent and photostable with the size ranging from 5 nm to 400 nm. Bioconjugation of these silica nanop...

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Bibliographic Details
Published in:Medicinal research reviews 2004-09, Vol.24 (5), p.621-638
Main Authors: Tan, Weihong, Wang, Kemin, He, Xiaoxiao, Zhao, Xiaojun Julia, Drake, Timothy, Wang, Lin, Bagwe, Rahul P.
Format: Article
Language:English
Subjects:
Animals
Bacteria - isolation & purification
Biomarkers - chemistry
bionanotechnology
Biosensing Techniques
Chemistry Techniques, Analytical - methods
Coloring Agents - chemistry
DNA - analysis
DNA - chemistry
Magnetics
Molecular Biology - methods
nanoparticles
Nanotechnology - methods
Nanotechnology - trends
Particle Size
Photobleaching
silica nanoparticles
Silicon Dioxide
Surface Properties
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Summary:We have developed uniform core/shell nanoparticles, consisting of a silica layer coating and pigments or magnetite core, using a water‐in‐oil microemulsion method. The nanoparticles are highly luminescent and photostable with the size ranging from 5 nm to 400 nm. Bioconjugation of these silica nanoparticles adds unique biofunctions with various molecules such as enzymes, antibodies, and DNA molecules. Significant advantages have been shown in using bioconjugated nanoparticles for biosensing and bioimaging, such as cell staining, DNA detection and separation, rapid single bacterium detection, and biotechnological application in DNA protection. © 2004 Wiley Periodicals, Inc. Med Res Rev, 24, No. 5, 621–638, 2004
ISSN:0198-6325
1098-1128
DOI:10.1002/med.20003