Assessment of respiratory symptoms with dual pH monitoring in patients with gastro-oesophageal reflux disease

Background: Gastro‐oesophageal reflux disease (GORD) is a commonly underestimated aetiological factor in patients with respiratory symptoms. In this study, acid reflux in healthy volunteers and patients with GORD with and without respiratory symptoms was investigated by dual pH monitoring. Methods:...

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Bibliographic Details
Published in:British journal of surgery 2004-07, Vol.91 (7), p.867-871
Main Authors: Kauer, W. K. H., Stein, H. J., Möbius, C., Siewert, J. R.
Format: Article
Language:English
Subjects:
Adult
Aged
Biological and medical sciences
Esophagus
Female
Gastric Acidity Determination
Gastroenterology. Liver. Pancreas. Abdomen
Gastroesophageal Reflux - complications
General aspects
Humans
Hydrogen-Ion Concentration
Male
Manometry
Medical sciences
Middle Aged
Other diseases. Semiology
Respiration Disorders - etiology
Respiration Disorders - physiopathology
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Summary:Background: Gastro‐oesophageal reflux disease (GORD) is a commonly underestimated aetiological factor in patients with respiratory symptoms. In this study, acid reflux in healthy volunteers and patients with GORD with and without respiratory symptoms was investigated by dual pH monitoring. Methods: Thirty healthy volunteers and 43 patients with GORD underwent oesophageal manometry and dual pH monitoring with one probe in the proximal and one in the distal oesophagus. Nineteen of the 43 patients complained of respiratory symptoms. Results: There were no differences in proximal probe measurements between volunteers and patients without respiratory symptoms. Patients with GORD and respiratory symptoms had a higher prevalence of abnormally high exposure to gastric juice and more reflux episodes in the proximal oesophagus compared with patients with GORD and no respiratory symptoms. Some 17 of 19 patients with GORD and respiratory symptoms showed deteriorated oesophageal body motility. Conclusion: Dual pH monitoring is feasible and well tolerated, and provides an objective means of evaluating patients with GORD and respiratory symptoms. Prolonged exposure of the proximal oesophagus to gastric juice and disorders of oesophageal body motility seem to be responsible for the development of respiratory symptoms. Copyright © 2004 British Journal of Surgery Society Ltd. Published by John Wiley & Sons, Ltd. Prolonged reflux causes respiratory symptoms
ISSN:0007-1323
1365-2168
DOI:10.1002/bjs.4551