Chemically Modified Carbon Paste Electrode for the Potentiometric Determination of Dicylomine Hydrochloride in Batch and in FIA Conditions

• Published in: Analytical Sciences 2004, Vol.20(6), pp.911-916
• Main Authors: IBRAHIM, H., ISSA, Y. M., ABU-SHAWISH, Hazem M.
• Format: Article
• Language: English
• Subjects: Amino acids; Carbon; Cations; Cholinergic Antagonists - analysis; Electrodes; Flow Injection Analysis - methods; Parasympatholytics - analysis
• ISSN: 0910-6340; 1348-2246
• DOI: 10.2116/analsci.20.911

A carbon-paste electrode for dicyclomine hydrochloride (DcCl) was prepared and fully characterized in terms of composition, life span, usable pH range and temperature. The electrode was applied to the potentiometric determination of dicylominium ion in its pure state and in pharmaceutical preparations in batch and flow injection conditions and in biological fluids using standard additions method. The electrode is based on a mixture of two ion-exchangers, namely, dicyclominium-phosphomolybdate and dicylominium-tetraphenylborate, dissolved in dioctyl phthalate as pasting liquid. The modified electrode showed a near-Nernstian slope of 58 ± 2 mV over the concentration range of 1.2 × 10-5 - 1.6 × 10-2 M with an average recovery of 97 - 102% and a RSD of 0.090 - 1.00. The electrode exhibits good selectivity for DcCl with respect to a large number of inorganic cations, sugars, amino acids and organic substances of biological fluids. Potentiometric titrations of DcCl with several titrants have been monitored using this modified carbon paste electrode as an end-point indicator electrode.