Factor V‐Leiden, prothrombin G20210A, and MTHFR C677T mutations among patients with sickle cell disease in Eastern Saudi Arabia

The prevalence of factor V Leiden, prothrombin G20210A, and MTHFR C677T mutations were investigated among 87 Saudi sickle cell disease (SCD) patients (38 males and 49 females) and 105 healthy controls (65 males and 40 females). The prevalences of factor V Leiden (P = 0.174) and PRT G20210A (P = 0.39...

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Published in:American journal of hematology 2004-07, Vol.76 (3), p.307-309
Main Authors: Fawaz, Naglaa A., Bashawery, Layla, Al‐Sheikh, Iman, Qatari, Ahlam, Al‐Othman, Sara S., Almawi, Wassim Y.
Format: Article
Language:English
Subjects:
Adolescent
Adult
Anemia, Sickle Cell - genetics
Anemias. Hemoglobinopathies
Biological and medical sciences
Child
Diseases of red blood cells
DNA Mutational Analysis
Factor V - genetics
Female
Hematologic and hematopoietic diseases
Heterozygote
Homozygote
Humans
hypercoagulation
Male
Medical sciences
Methylenetetrahydrofolate Reductase (NADPH2) - genetics
Middle Aged
Mutation
Prothrombin - genetics
risk factors
Saudi
Saudi Arabia
sickle cell disease
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Summary:The prevalence of factor V Leiden, prothrombin G20210A, and MTHFR C677T mutations were investigated among 87 Saudi sickle cell disease (SCD) patients (38 males and 49 females) and 105 healthy controls (65 males and 40 females). The prevalences of factor V Leiden (P = 0.174) and PRT G20210A (P = 0.397) were not different between patients and controls, thereby giving no support to an association of either single‐point mutation with SCD. However, an increased prevalence of the MTHFR 677 T/T genotype was seen among patients (8/87) compared to controls (4/105), but this was not statistically significant (P = 0.217; OR = 2.56). This suggested a low impact of inherited hypercoagulability risk factors in the pathogenesis of SCD and/or its complications. Am. J. Hematol. 76:307–309, 2004. © 2004 Wiley‐Liss, Inc.
ISSN:0361-8609
1096-8652
DOI:10.1002/ajh.20087