Lack of Arg972 Polymorphism in the IRS1 Gene in Parakanã Brazilian Indians

• Published in: Human biology 2004-02, Vol.76 (1), p.147-151
• Main Authors: BEZERRA, ROSÂNGELA M.N., CHADID, THIAGO T., ALTEMANI, CLAÚDIA M., SALES, TERESA S.I., MENEZES, RAIMUNDO, SOARES, MANOEL C.P., SAAD, SARA T.O., SAAD, MARIO J.A.
• Format: Article
• Language: English
• Subjects: Biological anthropology; Biology; Brazil; Brazil - epidemiology; Brazilians; Brief Communications; Codons; Consanguinity; Control groups; Diabetes; Diabetes mellitus; Diabetes Mellitus, Type 2 - genetics; Gene Frequency - genetics; Gene mutation; Gene mutations; Genes; Genetic aspects; Genetic mutation; Genetic polymorphisms; Genetic research; Human biology; Humans; Indians, South American - genetics; Insulin; Insulin resistance; Insulin Resistance - genetics; Leukocytes; Medical genetics; Native Americans; Polymerase Chain Reaction; Polymorphism; Polymorphism, Genetic - genetics; Prevalence; Receptors; Social Isolation; South Amerindians; Type 2 diabetes mellitus
• ISSN: 0018-7143; 1534-6617; 1534-6617
• DOI: 10.1353/hub.2004.0015

Several polymorphisms in the insulin receptor substrate-1 (IRS1) gene have been reported in the last years. The most common IRS1 variant, a Gly→Arg substitution at codon 972 (Arg972 IRS1), is more prevalent among subjects who have features of insulin resistance syndrome associated, or not, with type 2 diabetes in European populations. To determine whether the absence of 1RS 1 polymorphism is a more general characteristic of Paleo-Indian-derived populations, we examined the Arg972 1RS1 polymorphism in Parakanã Indians and found a lack of this polymorphism in the Parakanã population.