Distribution of 99mTc-labeled lymphocytes in control and inflamed rats

We studied the in vivo fate of CD8 + lymphocytes, of naive (CD8 +CD45RC bright) or memory (CD8 +CD45RC dim) phenotype, injected in syngeneic rats, after their sorting and labeling with [ 99mTc] HM-PAO. By using the scintigrafic method we showed that memory CD8 + lymphocytes were able to recirculate...

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Published in:Nuclear medicine and biology 2004-07, Vol.31 (5), p.631-638
Main Authors: Fulgenzi, Alessandro, Casati, Rosangela, Colombo, Fabio Riccardo, Gasparini, Massimo, Ferrero, Elisabetta, Bondanza, Attilio, Gerundini, Paolo, Ferrero, Maria Elena
Format: Article
Language:English
Subjects:
Animals
Cell homing
Inflammation
Inflammation - diagnostic imaging
Inflammation - metabolism
Lymphocytes
Lymphocytes - diagnostic imaging
Male
Metabolic Clearance Rate
Organ Specificity
Radionuclide Imaging
Radiopharmaceuticals - pharmacokinetics
Rat
Rats
Rats, Inbred F344
Rats, Inbred Strains
Scintigraphy
Technetium Tc 99m Exametazime - pharmacokinetics
Tissue Distribution
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Summary:We studied the in vivo fate of CD8 + lymphocytes, of naive (CD8 +CD45RC bright) or memory (CD8 +CD45RC dim) phenotype, injected in syngeneic rats, after their sorting and labeling with [ 99mTc] HM-PAO. By using the scintigrafic method we showed that memory CD8 + lymphocytes were able to recirculate into liver and lungs. The same method was also successfully used to in vivo study the homing of total blood lymphocytes obtained from inflamed rats.
ISSN:0969-8051
1872-9614
DOI:10.1016/j.nucmedbio.2004.01.004