Effect of dietary conjugated linoleic acid on liver regeneration after a partial hepatectomy in rats

• Published in: Journal of Nutritional Science and Vitaminology 2004, Vol.50(1), pp.9-12
• Main Authors: Hirao, A. (Kyushu Univ., Fukuoka (Japan). Faculty of Agriculture), Yamasaki, M, Chujo, H, Koyanagi, N, Kanouchi, H, Yasuda, S, Matsuo, A, Nishida, E, Rikimaru, T, Tsujita, E, Shimada, M, Maehara, Y, Tachibana, H, Yamada, K
• Format: Article
• Language: English
• Subjects: Alanine Transaminase - blood; Animals; Aspartate Aminotransferases - blood; Biological and medical sciences; Body Weight; conjugated linoleic acid; Dietary Fats, Unsaturated - administration & dosage; DNA; DNA - biosynthesis; DNA synthesis; Hepatectomy; LINOLEIC ACID; Linoleic Acids, Conjugated - administration & dosage; LIVER; Liver - anatomy & histology; Liver - metabolism; liver regeneration; Liver Regeneration - drug effects; Liver, biliary tract, pancreas, portal circulation, spleen; Male; MANKIND; Medical sciences; Organ Size; RATS; Rats, Sprague-Dawley; REGENERATIVE ABILITY; Safflower Oil - administration & dosage; Serum Albumin - analysis; Sprague-Dawley rats; Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases; Surgery of the digestive system
• ISSN: 0301-4800; 1881-7742
• DOI: 10.3177/jnsv.50.9

We examined the effect of dietary conjugated linoleic acid (CLA) on liver regeneration after a partial hepatectomy (PH) in Sprague-Dawley rats. PH Was performed on rats fed a 0 or 1 wt.% CLA diet for 3 wk. Average liver weight in the CLA fed rat popula-tion was heavier than the control rat population at the time of PH and 1-d after PH. Con-versely, CLA fed raduced liver weight was significantly lower than control rats at 7-d after PH. This suggests that dietary CLA reduced liver weight gain after PH. Dietary CLA did not affect serum aspartate aminotransferase (AST) or alanine aminotransferase (ALT) activities. How-ever, CLA significantly reduced serum albumin levels at 1-d but not at 7-d after PH. 5-Promo- and 5-iododeoxyuridine incorporation into hepatocytes 1-d post PH was lower in the CLA group. In conclusion, the data suggests that dietary CLA inhibits DNA synthesis after PH, which results in hepatocyte proliferation inhibition.