Experimental use of the attenuated Ehrlichia ruminantium (Welgevonden) vaccine in Merino sheep and Angora goats

Abstract The attenuated Ehrlichia ruminantium (Welgevonden) stock provides protection against a virulent homologous needle challenge in Merino sheep and Boer goats against heartwater. In this study, cryopreserved stabilates were tested for their suitability as a vaccine in Merino sheep. Vaccination...

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Bibliographic Details
Published in:Vaccine 2008-12, Vol.26, p.G34-G39
Main Authors: Zweygarth, Erich, Josemans, Antoinette I, Steyn, Helena C
Format: Article
Language:English
Subjects:
Allergy and Immunology
Angora goats
Animals
Animals, Domestic
Attenuated vaccine
Bacterial Vaccines - administration & dosage
Bacterial Vaccines - immunology
Cryopreservation
Ehrlichia ruminantium
Ehrlichia ruminantium - immunology
Goat Diseases - immunology
Goat Diseases - microbiology
Goat Diseases - prevention & control
Goats
Heartwater
Heartwater Disease - immunology
Heartwater Disease - microbiology
Heartwater Disease - prevention & control
Male
Merino sheep
Sheep
Sheep Diseases - immunology
Sheep Diseases - microbiology
Sheep Diseases - prevention & control
Treatment Outcome
Vaccination - veterinary
Vaccines, Attenuated - administration & dosage
Vaccines, Attenuated - immunology
Virulence
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Summary:Abstract The attenuated Ehrlichia ruminantium (Welgevonden) stock provides protection against a virulent homologous needle challenge in Merino sheep and Boer goats against heartwater. In this study, cryopreserved stabilates were tested for their suitability as a vaccine in Merino sheep. Vaccination did not produce disease and upon challenge with the virulent homologous stock all animals were fully protected. The vaccination protected all except one animal out of 5 challenged 12 months after immunization. The intramuscular route gave better protection than the subcutaneously applied vaccine. The attenuated vaccine was further evaluated in highly susceptible Angora goats. Although the attenuated vaccine showed an unexpectedly high degree of virulence, animals were fully protected against a lethal needle challenge.
ISSN:0264-410X
1873-2518
DOI:10.1016/j.vaccine.2008.09.068