Is procalcitonin a reliable marker for the diagnosis of infected pancreatic necrosis?

Background:  Infected necrosis in acute pancreatitis is the main factor in determining the prognosis of the disease. Early and accurate diagnosis of infected pancreatic necrosis might decrease mortality. The aim of the present study is to identify a reliable marker for the onset infection in three d...

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Published in:ANZ journal of surgery 2004-07, Vol.74 (7), p.591-595
Main Authors: Yonetci, Nadir, Sungurtekin, Ugur, Oruc, Nevin, Yilmaz, Mustafa, Sungurtekin, Hulya, Kaleli, Ilknur, Kaptanoglu, Bunyamin, Yuce, Gul, Ozutemiz, Omer
Format: Article
Language:English
Subjects:
Animals
Biomarkers - blood
Calcitonin - blood
Calcitonin Gene-Related Peptide
cerulein
Female
Necrosis
Pancreas - pathology
Pancreatic Diseases - blood
Pancreatic Diseases - diagnosis
Pancreatic Diseases - microbiology
pancreatic necrosis
pancreatitis
procalcitonin
Protein Precursors - blood
Rats
Rats, Wistar
Reproducibility of Results
taurocholate
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Summary:Background:  Infected necrosis in acute pancreatitis is the main factor in determining the prognosis of the disease. Early and accurate diagnosis of infected pancreatic necrosis might decrease mortality. The aim of the present study is to identify a reliable marker for the onset infection in three different experimentally induced pancreatitis models. Methods:  Ninety female Wistar albino rats were randomly divided into nine groups. In three different experimental models, including cerulein induced acute oedematous pancreatitis (AEP), sterile pancreatic necrosis due to taurocholate‐induced acute pancreatitis (SPN) and infected pancreatic necrosis taurocholate‐induced acute pancreatitis (IPN). Serum levels of procalcitonin (PCT), C‐reactive protein (CRP), tumour necrosis factor a (TNF‐α), interleukin 6 (IL‐6) and interleukin 8 (IL‐8), amylase were measured. The degree of pancreatic damage also evaluated pathologically. Results:  Procalcitonin levels were increased significantly in AEP, SPN and IPN compared to control groups (P 
ISSN:1445-1433
1445-2197
DOI:10.1111/j.1445-2197.2004.03059.x